Successful control of an outbreak of colonization by Klebsiella pneumoniae carbapenemase-producing K. pneumoniae sequence type 258 in a neonatal intensive care unit, Italy

被引：45

作者：

Giuffre, M. ^{[1
]}

Bonura, C. ^{[1
]}

Geraci, D. M. ^{[1
,2
]}

Saporito, L. ^{[1
]}

Catalano, R. ^{[1
,3
]}

Di Noto, S. ^{[1
,4
]}

Nociforo, F. ^{[1
,4
]}

Corsello, G. ^{[1
]}

Mammina, C. ^{[1
]}

机构：

[1] Univ Palermo, Dept Sci Hlth Promot & Mother Child Care G DAless, I-90127 Palermo, Italy

[2] Univ Palermo, PhD Sch Food & Human Nutr, I-90127 Palermo, Italy

[3] Univ Palermo, Postgrad Specialty Sch Prevent Med, I-90127 Palermo, Italy

[4] Univ Palermo, Postgrad Specialty Sch Pediat, I-90127 Palermo, Italy

来源：

JOURNAL OF HOSPITAL INFECTION | 2013年 / 85卷 / 03期

关键词：

Colonization; Infection control; KPC-Klebsiella pneumoniae; ST258; Multidrug resistance; Neonatal intensive care unit; SURVEILLANCE; INFECTIONS;

D O I：

10.1016/j.jhin.2013.08.004

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

This article reports an outbreak of colonization by Klebsiella pneumoniae carbapenemase-producing K. pneumoniae (KPC-Kp) sequence type (ST) 258 in a neonatal intensive care unit (NICU) in Palermo, Italy. KPC-Kp ST258 was detected by an active surveillance culture programme. Between 18th September and 14th November 2012, KPC-Kp was isolated from 10 out of 54 neonates admitted in the outbreak period. No cases of infection were recorded. Male sex was associated with colonization, whereas administration of ampicilline-sulbactam plus gentamicin was protective. Infection control interventions interrupted the spread of KPC-Kp without the need to close the NICU to new admissions. (C) 2013 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.

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页码：233 / 236

页数：4

相关论文

共 10 条

[1] Containment of an Outbreak of KPC-3-Producing Klebsiella pneumoniae in Italy [J].

Agodi, Antonella ;

Voulgari, Evangelia ;

Barchitta, Martina ;

Politi, Leda ;

Koumaki, Vasiliki ;

Spanakis, Nicholas ;

Giaquinta, Loredana ;

Valenti, Giovanna ;

Romeo, Maria Antonietta ;

Tsakris, Athanassios .

JOURNAL OF CLINICAL MICROBIOLOGY, 2011, 49 (11) :3986-3989

[2] Continuous Surveillance to Reduce Extended-Spectrum β-Lactamase Klebsiella pneumoniae Colonization in the Neonatal Intensive Care Unit [J].

Benenson, Shmuel ;

Levin, Phillip D. ;

Block, Colin ;

Adler, Amos ;

Ergaz, Zivanit ;

Peleg, Ofra ;

Minster, Naomi ;

Gross, Ilana ;

Schaffer, Keren ;

Moses, Allon E. ;

Cohen, Matan J. .

NEONATOLOGY, 2013, 103 (02) :155-160

[3]

European Centre for Disease Prevention and Control, 2011, ANN REP EUR ANT RES

[4] CDC DEFINITIONS FOR NOSOCOMIAL INFECTIONS, 1988 [J].

GARNER, JS ;

JARVIS, WR ;

EMORI, TG ;

HORAN, TC ;

HUGHES, JM .

AMERICAN JOURNAL OF INFECTION CONTROL, 1988, 16 (03) :128-140

[5] Outbreaks in neonatal intensive care units -: They are not like others [J].

Gastmeier, Petra ;

Loui, Andrea ;

Stamm-Balderjahn, Sabine ;

Hansen, Sonja ;

Zuschneid, Irina ;

Sohr, Dorit ;

Behnke, Michael ;

Obladen, Michael ;

Vonberg, Ralf-Peter ;

Rueden, Henning .

AMERICAN JOURNAL OF INFECTION CONTROL, 2007, 35 (03) :172-176

[6] Rapid detection of intestinal carriage of Klebsiella pneumoniae producing KPC carbapenemase during an outbreak [J].

Giani, T. ;

Tascini, C. ;

Arena, F. ;

Ciullo, I. ;

Conte, V. ;

Leonildi, A. ;

Menichetti, F. ;

Rossolini, G. M. .

JOURNAL OF HOSPITAL INFECTION, 2012, 81 (02) :119-122

[7] Outbreak of Infection with Klebsiella pneumoniae Sequence Type 258 Producing Klebsiella pneumoniae Carbapenemase 3 in an Intensive Care Unit in Italy [J].

Mammina, Caterina ;

Palma, Daniela Maria ;

Bonura, Celestino ;

Plano, Maria Rosa Anna ;

Monastero, Rachele ;

Sodano, Concetta ;

Cala, Cinzia ;

Tetamo, Romano .

JOURNAL OF CLINICAL MICROBIOLOGY, 2010, 48 (04) :1506-1507

[8] Surveillance of Multidrug-resistant Gram-negative Pathogens in High-risk Neonates-Does it Make a Difference? [J].

Simon, Arne ;

Tenenbaum, Tobias .

PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2013, 32 (04) :407-409

[9] Concordance of Gastrointestinal Tract Colonization and Subsequent Bloodstream Infections With Gram-negative Bacilli in Very Low Birth Weight Infants in the Neonatal Intensive Care Unit [J].

Smith, Ann ;

Saiman, Lisa ;

Zhou, Juyan ;

Della-Latta, Phyllis ;

Jia, Haomiao ;

Graham, Philip L., III .

PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2010, 29 (09) :831-835

[10] Multiresistant Gram-negative bacteria: the role of high-risk clones in the dissemination of antibiotic resistance [J].

Woodford, Neil ;

Turton, Jane F. ;

Livermore, David M. .

FEMS MICROBIOLOGY REVIEWS, 2011, 35 (05) :736-755