Branched-chain amino acid ratios modulate lipid metabolism in adipose tissues of growing pigs

被引：20
作者：
Duan, Yehui [1 ,2 ]
Li, Fengna [1 ,3 ]
Guo, Qiuping [1 ,2 ]
Wang, Wenlong [4 ]
Zhang, Lingyu [1 ,2 ]
Wen, Chaoyue [4 ]
Yin, Yulong [1 ,4 ]
机构：
[1] Chinese Acad Sci, Inst Subtrop Agr, Lab Anim Nutr Physiol & Metab Proc, Key Lab Agroecol Proc Subtrop Reg,Natl Engn Lab P, Changsha 410125, Hunan, Peoples R China
[2] Univ Chinese Acad Sci, Beijing 100039, Peoples R China
[3] Hunan Collaborat Innovat Ctr Utilizat Bot Funct I, Hunan Coinnovat Ctr Anim Prod Safety, CICAPS, Changsha, Hunan, Peoples R China
[4] Hunan Normal Univ, Sch Biol, Lab Anim Nutr & Human Hlth, Changsha 410018, Hunan, Peoples R China
来源：
JOURNAL OF FUNCTIONAL FOODS | 2018年 / 40卷
关键词：
Branched-chain amino acid ratio; Lipid metabolism; mTORC1; pathway; Mitochondrial biogenesis; Growing pigs; DIET-INDUCED OBESITY; LOW-PROTEIN DIETS; SKELETAL-MUSCLE; ADIPOCYTE DIFFERENTIATION; LEUCINE SUPPLEMENTATION; TRANSCRIPTIONAL CONTROL; THERAPEUTIC PROSPECTS; INSULIN SENSITIVITY; GROWTH-PERFORMANCE; MAMMALIAN TARGET;
D O I：
10.1016/j.jff.2017.12.004
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
The effects and roles of branched-chain amino acid (BCAAs) ratios in lipid metabolism in adipose tissues of pigs are still unkown. We used pigs (Large White x Landrace, 35 +/- 2 d) to investigate the effects of varying BCAA ratios (Leu: Ile: Val = 1:1:1, 1:0.75:0.75, 1:0.51:0.63, 1:0.25:0.25) on growth, carcass traits, and fat metabolism in adipose tissues. Results showed that as the ratio declined, the weight of total fat mass reduced while the adiponectin concentrations increased (P < .05), with the lowest/highest values observed in the 1:0.25:0.25 group, respectively. Moreover, varying BCAA ratios modulated the expression of genes related to adipose tissue function (P < .05). Concomitant with these changes, the 1:0.25:0.25 group increased/decreased the phosphorylation of AMPK alpha/mTOR, respectively (P < .05). The mRNA abundance of PGC-1 alpha and IL-15 were also increased in diets with BCAA ratios from 1:0.75:0.75 to 1:0.25:0.25. Our data suggest that dietary BCAA ratios in the adequate range, i.e. 1:0.75:0.75-1:0.25:0.25, modulate adipose tissue function including fatty acid synthesis, transport, and oxidation, lipolysis, and adipokine secretion. These effects are partly mediated by AMPK-mTOR pathway and associated with mitochondrial biogenesis, the AMPK-PGC-1 alpha axis, and IL-15 secreted by muscle tissues.
引用
收藏
页码：614 / 624
页数：11
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