Non-apoptotic cell death in malignant tumor cells and natural compounds

被引：88

作者：

Ye, Jing ^{[1
]}

Zhang, Ruonan ^{[2
,3
,4
]}

Wu, Fan ^{[7
]}

Zhai, Lijuan ^{[2
,3
,4
]}

Wang, Kaifeng ^{[2
,3
,4
]}

Xiao, Mang ^{[1
]}

Xie, Tian ^{[2
,3
,4
,5
,6
]}

Sui, Xinbing ^{[2
,3
,4
,5
,6
]}

机构：

[1] Zhejiang Univ, Coll Med, Sir Run Run Shaw Hosp, Dept Otolaryngol Head & Neck Surg, Hangzhou, Zhejiang, Peoples R China

[2] Hangzhou Normal Univ, Coll Med, Affiliated Hosp, Dept Med Oncol,Holist Integrat Oncol Inst, Hangzhou, Zhejiang, Peoples R China

[3] Hangzhou Normal Univ, Coll Med, Affiliated Hosp, Holist Integrat Canc Ctr Tradit Chinese & Western, Hangzhou, Zhejiang, Peoples R China

[4] Hangzhou Normal Univ, Coll Med, Holist Integrat Pharm Inst, Dept Canc Pharmacol, Hangzhou, Zhejiang, Peoples R China

[5] Hangzhou Normal Univ, Key Lab Elemene Class Anticanc Chinese Med Zhejia, Hangzhou, Zhejiang, Peoples R China

[6] Hangzhou Normal Univ, Engn Lab Dev & Applicat Tradit Chinese Med Zhejia, Hangzhou, Zhejiang, Peoples R China

[7] Des Moines Med Sch, Des Moines, IA USA

来源：

CANCER LETTERS | 2018年 / 420卷

基金：

中国国家自然科学基金;

关键词：

Natural compounds; Non-apoptotic cell death; Cancer; NF-KAPPA-B; ADENOCARCINOMA IN-VITRO; BREAST-CANCER; INDUCED AUTOPHAGY; LEUKEMIA-CELLS; DOCOSAHEXAENOIC ACID; SIGNALING PATHWAY; STRESS-RESPONSE; NECROPTOSIS; FERROPTOSIS;

D O I：

10.1016/j.canlet.2018.01.061

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Traditional cancer therapy is mainly targeting on enhancing cell apoptosis, however, it is well established that many cancer cells are chemo-resistant and defective in apoptosis induction. Therefore, it may have important therapeutic implications to exploit some novel natural compounds based on non-apoptotic programmed cell death. Currently, accumulating evidence shows that the compounds from nature source can induce non-apoptotic programmed cell death in cancer cells, and therefore these natural compounds have gained a great promise for the future anticancer therapeutics. In this review, we will concentrate our efforts on the latest developments regarding major forms of non-apoptotic programmed cell death-autophagic cell death, necroptosis, ferroptosis, pyroptosis, glutamoptosis and exosome-associated cell death. Our increased understanding of the role of natural compounds in regulating non-apoptotic programmed cell death will hopefully provide prospective strategies for cancer therapy. (C) 2018 Elsevier B.V. All rights reserved.

引用

页码：210 / 227

页数：18

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