Total Synthesis of Calothrixin B and Its Analogs

被引：23

作者：

Saravanan, Velu ^{[1
]}

Ramalingam, Bose Muthu ^{[1
]}

Mohanakrishnan, Arasambattu K. ^{[1
]}

机构：

[1] Univ Madras, Dept Organ Chem, Madras 600025, Tamil Nadu, India

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2014年 / 2014卷 / 06期

关键词：

Total synthesis; Natural products; Alkaloids; Nitrogen heterocycles; Electrocyclic reactions; Cyclization; DOMINO REACTION; CYANOBACTERIA; ROUTE;

D O I：

10.1002/ejoc.201301524

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The total synthesis of calothrixin B and its analogs was achieved starting from 2-methylindole. The synthesis involved an electrocyclization of 2-nitroarylvinyl-3-phenylsulfonylvinylindoles as a key step to give 2-nitroaryl-4-methoxy-3-methylcarbazoles. Oxidation of these compounds followed by reductive cyclization led to N-phenylsulfonylquinocarbazoles. These quinocarbazoles underwent hydrolysis and aerial oxidation in one pot to give the target compounds.

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页码：1266 / 1279

页数：14

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