Bat and Rat Neurons Differ in Theta-Frequency Resonance Despite Similar Coding of Space

被引：39

作者：

Heys, James G. ^{[1
]}

MacLeod, Katrina M. ^{[2
]}

Moss, Cynthia F. ^{[3
]}

Hasselmo, Michael E. ^{[4
]}

机构：

[1] Boston Univ, Ctr Memory & Brain, Grad Program Neurosci, Boston, MA 02215 USA

[2] Univ Maryland, Dept Biol, College Pk, MD 20742 USA

[3] Univ Maryland, Dept Psychol, College Pk, MD 20742 USA

[4] Boston Univ, Ctr Memory & Brain, Dept Psychol, Boston, MA 02215 USA

来源：

SCIENCE | 2013年 / 340卷 / 6130期

基金：

美国国家科学基金会;

关键词：

MEDIAL ENTORHINAL CORTEX; GRID CELLS; STELLATE CELLS; LAYER-II; SUBTHRESHOLD OSCILLATIONS; SPATIAL PERIODICITY; HCN1; CHANNELS; ORGANIZATION; MAP; MODELS;

D O I：

10.1126/science.1233831

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Both bats and rats exhibit grid cells in medial entorhinal cortex that fire as they visit a regular array of spatial locations. In rats, grid-cell firing field properties correlate with theta-frequency rhythmicity of spiking and membrane-potential resonance; however, bat grid cells do not exhibit theta rhythmic spiking, generating controversy over the role of theta rhythm. To test whether this discrepancy reflects differences in rhythmicity at a cellular level, we performed whole-cell patch recordings from entorhinal neurons in both species to record theta-frequency resonance. Bat neurons showed no theta-frequency resonance, suggesting grid-cell coding via different mechanisms in bats and rats or lack of theta rhythmic contributions to grid-cell firing in either species.

引用

页码：363 / 367

页数：5

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