Inhibition of protein phosphatase 2A by cantharidin analogues.

被引：46

作者：

McCluskey, A

Taylor, C

Quinn, RJ

Suganuma, M

Fujiki, H

机构：

[1] GRIFFITH UNIV,BRISBANE,QLD 4111,AUSTRALIA

[2] SAITAMA CANC CTR,RES INST,INA,SAITAMA 362,JAPAN

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 09期

关键词：

D O I：

10.1016/0960-894X(96)00166-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The syntheses of several cantharidin analogues and their biochemical effects on protein phosphatase 2A are described. Comparison of the PP2A inhibition of these cantharidin analogues has shown that the 7-oxo moiety and the anhydride system contribute to the biochemical activity. The diacid forms of several anhydrides showed reduced inhibition of PP2A. (C) 1996 Elsevier Science Ltd.

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页码：1025 / 1028

页数：4

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