Eight new biflavonoids with lavandulyl units from the roots of Sophora flavescens and their inhibitory effect on PTP1B

被引：27

作者：

Yan, Hai-Wei ^{[1
,2
]}

Zhu, Hui ^{[1
,2
]}

Yuan, Xiang ^{[1
,2
]}

Yang, Ya-Nan ^{[1
,2
,3
]}

Feng, Zi-Ming ^{[1
,2
]}

Jiang, Jian-Shuang ^{[1
,2
]}

Zhang, Pei-Cheng ^{[1
,2
]}

机构：

[1] Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China

[2] Peking Union Med Coll, Beijing 100050, Peoples R China

[3] Guizhou Med Univ, State Key Lab Funct & Applicat Med Plants, Guiyang 550025, Guizhou, Peoples R China

来源：

BIOORGANIC CHEMISTRY | 2019年 / 86卷

关键词：

Sophora flavescens; Biflavonoids; Sophobiflavonoids A-H; PTP1B inhibitory activity; FLAVONOIDS; ANTIBACTERIAL; EXTRACT;

D O I：

10.1016/j.bioorg.2019.01.058

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In the course of studying the components from the roots of Sophora flavescens, eight new unusual biflavonoids consisting of a flavanone fused with a dihydrochalcone skeleton were isolated. These new chemical structures were elucidated by means of UV, IR, HRESIMS, NMR and ECD spectroscopic data and a comparison of experimental ECD spectra with calculated ECD spectra. Some compounds were subjected to an antidiabetic bioassay on human recombinant PTP1B inhibition, and showed strong inhibitory activity.

引用

收藏

页码：679 / 685

页数：7

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