Microprobe X-ray absorption spectroscopic determination of the oxidation state of intracellular chromium following exposure of V79 Chinese hamster lung cells to genotoxic chromium complexes

被引：44
作者：
Dillon, CT
Lay, PA
Cholewa, M
Legge, GJF
Bonin, AM
Collins, TJ
Kostka, KL
SheaMcCarthy, G
机构：
[1] UNIV SYDNEY, SCH CHEM, SYDNEY, NSW 2006, AUSTRALIA
[2] UNIV MELBOURNE, SCH PHYS, MICRO ANALYT RES CTR, PARKVILLE, VIC 3052, AUSTRALIA
[3] INST NUCL PHYS, KRAKOW, POLAND
[4] WORKSAFE AUSTRALIA, SYDNEY, NSW 2001, AUSTRALIA
[5] CARNEGIE MELLON UNIV, DEPT CHEM, PITTSBURGH, PA 15213 USA
[6] UNIV CHICAGO, CARS, NATL SYNCHROTRON LIGHT SOURCE DEPT, BROOKHAVEN NATL LAB, UPTON, NY 11973 USA
来源：
CHEMICAL RESEARCH IN TOXICOLOGY | 1997年 / 10卷 / 05期
关键词：
D O I：
10.1021/tx970010m
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The oxidation state of intracellular chromium has been determined directly in mammalian lung cells exposed to mutagenic and carcinogenic chromium compounds. Microprobe X-ray absorption spectroscopy (XAS) experiments on single V79 Chinese hamster lung cells showed that Cr(VI) and Cr(V) complexes were reduced completely (>90%) to Cr(III) within 4 h of exposure of the cells. This result provides direct evidence for the hypothesis that these genotoxic oxidants react rapidly with intracellular reductants.
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页码：533 / 535
页数：3
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