Significance of ELF3 mRNA Expression for Detection of Lymph Node Metastases of Colorectal Cancer

被引：0

作者：

Nakarai, Chiaki

Osawa, Kayo ^{[1
]}

Matsubara, Nagahide ^{[2
]}

Ikeuchi, Hiroki ^{[2
]}

Yamano, Tomoki ^{[2
]}

Okamura, Shu ^{[3
]}

Kamoshida, Shingo

Tsutou, Akimitsu

Takahashi, Juro

Ejiri, Kazushige ^{[4
]}

Hirota, Seiichi ^{[5
]}

Tomita, Naohiro ^{[2
]}

Kido, Yoshiaki ^{[6
]}

机构：

[1] Kobe Univ, Grad Sch Hlth Sci, Fac Hlth Sci, Dept Biophys,Suma Ku, Kobe, Hyogo 6540142, Japan

[2] Hyogo Coll Med, Dept Surg, Nishinomiya, Hyogo 6638501, Japan

[3] Kansai Rosai Hosp, Dept Surg, Amagasaki, Hyogo, Japan

[4] Joyo Ejiri Hosp, Dept Internal Med, Himeji, Hyogo, Japan

[5] Hyogo Coll Med, Dept Surg Pathol, Nishinomiya, Hyogo 6638501, Japan

[6] Kobe Univ, Grad Sch Med, Dept Internal Med, Div Diabet & Endocrinol, Kobe, Hyogo 6540142, Japan

来源：

ANTICANCER RESEARCH | 2012年 / 32卷 / 09期

关键词：

ELF3/ESE-1/ESX/ERT/jen; lymph node metastasis; colorectal cancer; real-time quantitative PCR; COLON-CANCER; GENOMIC ORGANIZATION; EPITHELIAL-CELLS; TUMOR DEPOSITS; RT-PCR; GENE; IDENTIFICATION; PROMOTER; MICROMETASTASES; DISEASE;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Lymph node (LN) evaluation is an important factor for the prognosis of colorectal cancer (CRC). The purpose of our study was to investigate the effectiveness of E74-like factor 3 (ELF3) and carcinoembryonic antigen (CEA) as useful markers to detect LN metastases in CRC. Materials and Methods: We examined the mRNA expression of ELF3 and CEA in LNs and tissues from 22 patients with CRC and in controls with ulcerative colitis (UC) by real-time quantitative reverse transcription polymerase chain reaction, as well as by hematoxylin eosin staining. Results: ELF3 and CEA expression showed statistically significant differences among four LN groups: LNs from patients with CRC categorized into three Dukes' stages and LNs from patients with UC (p<0.001 and p<0.001, respectively). We found a statistical correlation between the expression levels of both markers in patients with CRC compared with each Dukes' stage. Conclusion: ELF3, as a gene marker, may be sufficiently practical to detect LN metastases of CRC, rather than CEA.

引用

页码：3753 / 3758

页数：6

共 26 条

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