The aging paradox: free radical theory of aging

被引：239

作者：

Ashok, BT ^{[1
]}

Ali, R ^{[1
]}

机构：

[1] Aligarh Muslim Univ, JN Med Coll, Dept Biochem, Aligarh 202002, Uttar Pradesh, India

来源：

EXPERIMENTAL GERONTOLOGY | 1999年 / 34卷 / 03期

关键词：

aging; autoantibodies; DNA damage; free radicals; reactive oxygen species;

D O I：

10.1016/S0531-5565(99)00005-4

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

There are more than 300 theories to explain the aging phenomenon. Many of them originate from the study of changes that accumulate with time. Among all the theories, the free radical theory of aging, postulated first by Harman, is the most popular and widely tested, and is based on the chemical nature and ubiquitous presence of free radicals. This review aims to recapitulate various studies on the role of free radicals in DNA damage-both nuclear as well as mitochondrial-the oxidative stress they impose on cells, the role of antioxidants, the presence of autoantibodies, and their overall impact on the aging process. (C) 1999 Elsevier Science Inc. All rights reserved.

引用

页码：293 / 303

页数：11

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