The p38 and Hog1 SAPKs control cell cycle progression in response to environmental stresses

被引：56

作者：

Duch, Alba

de Nadal, Eulalia ^{[1
]}

Posas, Francesc ^{[1
]}

机构：

[1] Univ Pompeu Fabra, Cell Signaling Res Grp, Dept Ciencies Expt & Salut, Cell Signaling Unit, E-08003 Barcelona, Spain

来源：

FEBS LETTERS | 2012年 / 586卷 / 18期

关键词：

Stress-response; SAPK; Cell cycle regulation; ACTIVATED PROTEIN-KINASE; SIGNAL-TRANSDUCTION PATHWAY; DNA-DAMAGE RESPONSE; S-PHASE; SACCHAROMYCES-CEREVISIAE; GENE-EXPRESSION; MAP KINASES; MORPHOGENESIS CHECKPOINT; DEPENDENT KINASES; HYPERTONIC STRESS;

D O I：

10.1016/j.febslet.2012.07.034

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In response to environmental stresses, cells need to activate an adaptive program to maximize cell progression and survival. Stress-activated protein kinases (SAPK) are key signal transduction kinases required to respond to stress. Prototypical members of SAPKs are the yeast Hog1 and mammalian p38. Upon stress, those enzymes play a critical role in mounting the adaptive responses to stress such as the regulation of metabolism and the control of gene expression. In addition, a major function of SAPKs in response to stress is to modulate cell cycle progression. In this review, we focus on the role of Hog1 and p38 in the control of cell cycle progression in response to environmental stresses. (C) 2012 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

引用

页码：2925 / 2931

页数：7

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