Developing mRNA-vaccine technologies

被引：449
作者：
Schlake, Thomas [1 ]
Thess, Andreas [1 ]
Fotin-Mleczek, Mariola [1 ]
Kallen, Karl-Josef [1 ]
机构：
[1] CureVac GmbH, Tubingen, Germany
来源：
RNA BIOLOGY | 2012年 / 9卷 / 11期
关键词：
mRNA; adjuvant; vaccine; mRNA production; mRNA design; mRNA uptake; formulation; protein expression; DOUBLE-STRANDED-RNA; CYTOTOXIC T-LYMPHOCYTES; RECEPTOR-MEDIATED ENDOCYTOSIS; ANTIGEN-PRESENTING CELLS; HUMAN DENDRITIC CELLS; IN-VIVO; IMMUNE-RESPONSES; POLY(A) TAIL; CAP-ANALOGS; PROTEIN EXPRESSION;
D O I：
10.4161/rna.22269
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
mRNA vaccines combine desirable immunological properties with an outstanding safety profile and the unmet flexibility of genetic vaccines. Based on in situ protein expression, mRNA vaccines are capable of inducing a balanced immune response comprising both cellular and humoral immunity while not subject to MHC haplotype restriction. In addition, mRNA is an intrinsically safe vector as it is a minimal and only transient carrier of information that does not interact with the genome. Because any protein can be expressed from mRNA without the need to adjust the production process, mRNA vaccines also offer maximum flexibility with respect to development. Taken together, mRNA presents a promising vector that may well become the basis of a game-changing vaccine technology platform. Here, we outline the current knowledge regarding different aspects that should be considered when developing an mRNA-based vaccine technology.
引用
收藏
页码：1319 / 1330
页数：12
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