Molecular recognition of nitrated fatty acids by PPARγ

被引：137

作者：

Li, Yong ^{[1
,2
]}

Zhang, Jifeng ^{[3
]}

Schopfer, Francisco J.

Martynowski, Dariusz ^{[1
]}

Garcia-Barrio, Minerva T. ^{[5
]}

Kovach, Amanda ^{[2
]}

Suino-Powell, Kelly ^{[2
]}

Baker, Paul R. S.

Freeman, Bruce A. ^{[4
]}

Chen, Y. Eugene ^{[3
]}

Xu, H. Eric ^{[2
]}

机构：

[1] Univ Pittsburgh, Ctr Pharmacogenet, Dept Pharmaceut Sci, Pittsburgh, PA 15261 USA

[2] Van Andel Res Inst, Lab Struct Sci, Grand Rapids, MI 49503 USA

[3] Univ Michigan, Med Ctr, Dept Internal Med, Ctr Cardiovasc, Ann Arbor, MI 48109 USA

[4] Univ Pittsburgh, Dept Pharmacol & Chem Biol, Pittsburgh, PA 15261 USA

[5] Morehouse Sch Med, Cardiovasc Res Inst, Atlanta, GA 30310 USA

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2008年 / 15卷 / 08期

关键词：

D O I：

10.1038/nsmb.1447

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Peroxisome proliferator activated receptor-gamma (PPAR gamma) regulates metabolic homeostasis and adipocyte differentiation, and it is activated by oxidized and nitrated fatty acids. Here we report the crystal structure of the PPAR gamma ligand binding domain bound to nitrated linoleic acid, a potent endogenous ligand of PPAR gamma. Structural and functional studies of receptor-ligand interactions reveal the molecular basis of PPAR gamma discrimination of various naturally occurring fatty acid derivatives.

引用

页码：865 / 867

页数：3

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