Reflux inhibitors - new therapy of gastroesophageal reflux disease

被引：0

作者：

Jurkowska, Grazyna ^{[1
]}

Swidnicka-Siergiejko, Agnieszka ^{[1
]}

Dabrowski, Andrzej ^{[1
]}

机构：

[1] Uniwersytet Med Bialymstoku, Klin Gastroenterol & Chorob Wewnetrznych, PL-15276 Bialystok, Poland

来源：

PRZEGLAD GASTROENTEROLOGICZNY | 2012年 / 7卷 / 02期

关键词：

gastroesophageal reflux; transient lower esophageal sphincter relaxation; GABA receptors; glutamate receptors; ESOPHAGEAL SPHINCTER RELAXATIONS; NEGATIVE ALLOSTERIC MODULATOR; AGONIST BACLOFEN; SYMPTOMS; ADX10059; ACID; IMPEDANCE; EFFICACY; HERNIA;

D O I：

10.5114/pg.2012.28645

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The most relevant target for the treatment of refractory gastroesophageal reflux disease (GERD) is controlling the occurrence of transient lower esophageal relaxations (TLESR), which represent the main mechanism of all types of reflux. Drugs in development that have this mechanism of action are now described as reflux inhibitors. The most promising among these appear to be mGluR5 agonists and GABA(B) receptor agonists, which reduce the number of reflux episodes and improve reflux-related symptoms. Reflux inhibitors appear to have a potential role in the management of refractory GERD as add-on therapy in combination with PPI. Future studies will establish the safety and tolerability of the new anti-reflux therapy.

引用

收藏

页码：57 / 62

页数：6

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