The Effect of Cannabis sativa Hydroalcoholic Extract on Sperm Parameters and Testis Histology in Rats

被引：13
作者：
Lotfi, Nahid [1 ]
Khazaei, Mozafar [1 ]
Shariatzadeh, Sayyed Mohammad Ali [2 ]
Mehranjani, Malek Soleimani [2 ]
Ghanbari, Ali [1 ]
机构：
[1] Kermanshah Univ Med Sci, Fertil & Infertil Res Ctr, Kermanshah, Iran
[2] Univ Arak, Fac Sci, Dept Biol, Arak, Iran
来源：
INTERNATIONAL JOURNAL OF MORPHOLOGY | 2013年 / 31卷 / 01期
关键词：
Cannabis sativa; Rat; Seminiferous tubules; Sperm parameters; LIPID-PEROXIDATION; RECEPTOR; ANANDAMIDE; EXPRESSION; MOTILITY;
D O I：
10.4067/S0717-95022013000100012
中图分类号：
R602 [外科病理学、解剖学]; R32 [人体形态学];
学科分类号：
100101 ;
摘要：
Cannabis Sativa is a multiuse herb in traditional medicine, its hydroalcoholic extract (10, 50, and 100 mg/kg) administered interaperitoneally for 14 consequent days to Wistar male rats resulted in significant decrease in progressive motility of sperm. Sperm count and seminiferous tubules diameter decreased significantly in comparison with control group. Also decrease in animal body weight in doses of 50 and 100 mg/kg was observed. Changes in testes weight and serum testosterone were not significant. Cannabis sativa extract has negative effect on sperm parameters such as motility, sperm count, and seminiferous tubules diameter.
引用
收藏
页码：82 / 86
页数：5
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