Out of the jaws of death: PRMT5 steers p53

被引：20

作者：

Berger, Shelley L. ^{[1
]}

机构：

[1] Wistar Inst Anat & Biol, Gene Express & Regulat Program, Philadelphia, PA 19104 USA

来源：

NATURE CELL BIOLOGY | 2008年 / 10卷 / 12期

关键词：

D O I：

10.1038/ncb1208-1389

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The tumour suppressor p53 triggers either cell-cycle arrest or apoptosis. Now, arginine methylation joins a panoply of other post-translational modifications that regulate p53. PRMT5 mediates p53 methylation, which disposes the cell to arrest rather than death.

引用

页码：1389 / 1390

页数：2

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