Comparison of Immune Cell Recruitment and Function in Endometrium During Development of Epitheliochorial (Pig) and Hemochorial (Mouse and Human) Placentas

被引：41
作者：
Croy, B. A. [1 ]
Wessels, J. [2 ]
Linton, N. [2 ]
Tayade, C. [2 ]
机构：
[1] Queens Univ, Dept Anat & Cell Biol, Kingston, ON K7L 3N6, Canada
[2] Univ Guelph, Dept Biomed Sci, Ontario Vet Coll, Guelph, ON N1G 2W1, Canada
来源：
PLACENTA | 2009年 / 30卷
基金：
加拿大自然科学与工程研究理事会;
关键词：
Angiogenesis; Chemokine; Chemokine decoy; Dendritic cell; Lymphocyte; Trophoblast; Uterine Natural Killer cell; NATURAL-KILLER-CELLS; ENDOTHELIAL GROWTH-FACTOR; METRIAL GLAND-CELLS; TOLL-LIKE RECEPTORS; NK CELLS; DECIDUAL LYMPHOCYTES; EMBRYONIC ATTACHMENT; INTERFERON-GAMMA; GENE-EXPRESSION; DENDRITIC CELLS;
D O I：
10.1016/j.placenta.2008.09.019
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The role of maternal immune cells in early implantation sites has received special attention from reproductive biologists because immune cells participate in tissue transplant rejection. During normal pregnancy, endometrial immune cells differ from those in blood by subset distribution and appear to be activated but non-destructive of conceptuses. The immune system evolved well before placental mammals. By comparing the regulation and functions of endometrial immune cells between species in two phylogenetic clades that model differently evolved placental types (pig (Sus scrofa) versus mouse (Mus musculus) and human (Homo sapiens)), we seek to understand how "non-self' trophoblast cells thrive in most pregnancies. Our studies suggest recruitment of specific immune cells to conceptus-associated endometrium and immune cell-promoted endometrial angiogenesis are of key importance for mammalian conceptus well-being. (C) 2009 Published by IFPA and Elsevier Ltd
引用
收藏
页码：S26 / S31
页数：6
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