mTORC1 and Nutrient Homeostasis: The Central Role of the Lysosome

被引:127
|
作者
Rabanal-Ruiz, Yoana [1 ]
Korolchuk, Viktor I. [1 ]
机构
[1] Newcastle Univ, Inst Cell & Mol Biosci, Newcastle Upon Tyne NE4 5PL, Tyne & Wear, England
基金
英国生物技术与生命科学研究理事会;
关键词
mTOR; nutrient sensing; lysosome; growth; autophagy; AMINO-ACID TRANSPORTERS; NOVO PYRIMIDINE SYNTHESIS; TRANSFER-RNA SYNTHETASE; VACUOLAR H+-ATPASE; RAG GTPASES; TUMOR-SUPPRESSOR; KINASE-ACTIVITY; LEUCINE SENSOR; V-ATPASE; TRANSCRIPTION FACTORS;
D O I
10.3390/ijms19030818
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The mechanistic target of rapamycin complex 1 (mTORC1) coordinates cellular growth and metabolism with environmental inputs to ensure that cells grow only under favourable conditions. When active, mTORC1 stimulates biosynthetic pathways including protein, lipid and nucleotide synthesis and inhibits cellular catabolism through repression of the autophagic pathway, thereby promoting cell growth and proliferation. The recruitment of mTORC1 to the lysosomal surface has been shown to be essential for its activation. This finding has significantly enhanced our knowledge of mTORC1 regulation and has focused the attention of the field on the lysosome as a signalling hub which coordinates several homeostatic pathways. The intriguing localisation of mTORC1 to the cellular organelle that plays a crucial role in catabolism enables mTORC1 to feedback to autophagy and lysosomal biogenesis, thus leading mTORC1 to enact precise spatial and temporal control of cell growth. This review will cover the signalling interactions which take place on the surface of lysosomes and the cross-talk which exists between mTORC1 activity and lysosomal function.
引用
收藏
页数:23
相关论文
共 50 条
  • [21] Central role of mTORC1 downstream of YAP/TAZ in hepatoblastoma development
    Liu, Pin
    Calvisi, Diego F.
    Kiss, Andras
    Cigliano, Antonio
    Schaff, Zsuzsa
    Che, Li
    Ribback, Silvia
    Dombrowski, Frank
    Zhao, Dongchi
    Chen, Xin
    ONCOTARGET, 2017, 8 (43) : 73433 - 73447
  • [22] The necessary role of mTORC1 in central nervous system axon regeneration
    Yang Hu
    NeuralRegenerationResearch, 2015, 10 (02) : 186 - 188
  • [23] Regulation of colonic epithelial cell homeostasis by mTORC1
    Kotani, Takenori
    Setiawan, Jajar
    Konno, Tasuku
    Ihare, Noriko
    Okamoto, Saki
    Saito, Yasuyuki
    Murata, Yoji
    Noda, Tetsuo
    Matozaki, Takashi
    SCIENTIFIC REPORTS, 2020, 10 (01)
  • [24] Caloric Restriction in mTORC1 Control of Intestinal Homeostasis
    Harris, Thurl E.
    Thorner, Michael O.
    CELL METABOLISM, 2012, 16 (01) : 6 - 8
  • [25] Protein kinase C controls lysosome biogenesis independently of mTORC1
    Yang Li
    Meng Xu
    Xiao Ding
    Chen Yan
    Zhiqin Song
    Lianwan Chen
    Xiahe Huang
    Xin Wang
    Youli Jian
    Guihua Tang
    Changyong Tang
    Yingtong Di
    Shuzhen Mu
    Xuezhao Liu
    Kai Liu
    Ting Li
    Yingchun Wang
    Long Miao
    Weixiang Guo
    Xiaojiang Hao
    Chonglin Yang
    Nature Cell Biology, 2016, 18 : 1065 - 1077
  • [26] Protein kinase C controls lysosome biogenesis independently of mTORC1
    Li, Yang
    Xu, Meng
    Ding, Xiao
    Yan, Chen
    Song, Zhiqin
    Chen, Lianwan
    Huang, Xiahe
    Wang, Xin
    Jian, Youli
    Tang, Guihua
    Tang, Changyong
    Di, Yingtong
    Mu, Shuzhen
    Liu, Xuezhao
    Liu, Kai
    Li, Ting
    Wang, Yingchun
    Miao, Long
    Guo, Weixiang
    Hao, Xiaojiang
    Yang, Chonglin
    NATURE CELL BIOLOGY, 2016, 18 (10) : 1065 - 1077
  • [27] Lysosome identity crisis: Phosphoinositides and mTORC1 negotiate lysosomal behavior
    Mansat, Melanie
    Botelho, Roberto J.
    MOLECULAR CELL, 2024, 84 (01) : 17 - 19
  • [28] Nutrient Sensor OGT Regulates Glucose Homeostasis through β-Cell Autophagy via mTORC1 Pathway
    Jo, Seokwon
    Alejandro, Emilyn
    DIABETES, 2022, 71
  • [29] An expanded role for mTORC1 in autophagy
    Kim, Young-Mi
    Park, Ji-Man
    Grunwald, Douglas
    Kim, Do-Hyung
    MOLECULAR & CELLULAR ONCOLOGY, 2016, 3 (01):
  • [30] Nutrient sensing of mTORC1 signaling in cancer and aging
    Jiang, Cong
    Tan, Xiao
    Liu, Ning
    Yan, Peiqiang
    Hou, Tao
    Wei, Wenyi
    SEMINARS IN CANCER BIOLOGY, 2024, 106-107 : 1 - 12