Sex-specific associations of blood and urinary manganese levels with glucose levels, insulin resistance and kidney function in US adults: National health and nutrition examination survey 2011-2016

被引:49
作者
Yang, Jingli [1 ]
Yang, Aimin [2 ]
Cheng, Ning [3 ]
Huang, Wenya [1 ]
Huang, Peiyao [1 ]
Liu, Nian [1 ]
Bai, Yana [1 ]
机构
[1] Lanzhou Univ, Coll Earth & Environm Sci, Sch Publ Hlth, Dept Epidemiol & Stat, Lanzhou, Gansu, Peoples R China
[2] Chinese Univ Hong Kong, Prince Wales Hosp, Dept Med & Therapeut, Hong Kong, Peoples R China
[3] Lanzhou Univ, Dept Basic Med, Lanzhou, Gansu, Peoples R China
关键词
Diabetes mellitus; Glucose; Insulin resistance; Kidney function tests; Manganese; Metals; FASTING PLASMA-GLUCOSE; SUPEROXIDE-DISMUTASE; RISK; HORMONES; METALS; TRANSPORT; EXPOSURE; WOMEN; MODEL;
D O I
10.1016/j.chemosphere.2020.126940
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Exposures to heavy metals play a role in the etiopathogenesis of diabetes. Epidemiological studies investigating a potential sex-specific linkage between manganese (Mn) exposures and glucose homeostasis are rare. We comprehensively estimated the associations of blood and urinary Mn levels with fasting plasma glucose (FPG), hemoglobin A1c (HbA1c), homeostasis model assessment for insulin resistance (HOMA-IR), insulin, and estimated glomerular filtration rate (eGFR) among 1417 adults in the US National Health and Nutrition Examination Survey (NHANES) 2011-2016. We further examined the potential heterogeneities by sex and joint-effects of multiple metal exposures by the Bayesian kernel machine regression (BKMR). Among women, we found positive linear relationships between urinary Mn with FPG (P-overall = 0.003, P-nonlinear = 0.817) and HbA1c (P-overall = 0.023, P-nonlinear = 0.854). Among men, J-shaped relationships were observed between blood Mn with HOMA-IR (P-nonlinear = 0.042) and insulin (P-nonlinear = 0.014). For eGFR, positive linear relationships were obserned among women for blood Mn (P-nonlinear = 0.549) and among both men and women for urinary Mn levels. The joint-effects of urinary Mn with molybdenum (Mo) on FPG and HbA1c, urinary Mn with cadmium (Cd) and cesium (Cs) on eGFR, and blood Mn with Cd and lead (Pb) on eGFR were detected. In summary, blood and urinary Mn levels were independently associated with glucose levels, insulin resistance and kidney function with potential sex-dependent heterogeneities. These findings emphasize the probable role of Mn in the regulation of glucose metabolism and kidney function, and confirm the need for more studies on sex-specific risk of diabetes. (C) 2020 Published by Elsevier Ltd.
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页数:10
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共 47 条
[21]   Altered Metabolism of Blood Manganese Is Associated with Low Levels of Hemoglobin in Patients with Chronic Kidney Disease [J].
Kim, Minyoung ;
Koh, Eun Sil ;
Chung, Sungjin ;
Chang, Yoon Sik ;
Shin, Seok Joon .
NUTRIENTS, 2017, 9 (11)
[22]   Association of blood manganese level with diabetes and renal dysfunction: a cross-sectional study of the Korean general population [J].
Koh, Eun Sil ;
Kim, Sung Jun ;
Yoon, Hye Eun ;
Chung, Jong Hee ;
Chung, Sungjin ;
Park, Cheol Whee ;
Chang, Yoon Sik ;
Shin, Seok Joon .
BMC ENDOCRINE DISORDERS, 2014, 14
[23]   Commentary: Environmental chemicals and diabetes: which ones are we missing? [J].
Kuo, Chin-Chi ;
Navas-Acien, Ana .
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 2015, 44 (01) :248-250
[24]   A New Equation to Estimate Glomerular Filtration Rate [J].
Levey, Andrew S. ;
Stevens, Lesley A. ;
Schmid, Christopher H. ;
Zhang, Yaping ;
Castro, Alejandro F., III ;
Feldman, Harold I. ;
Kusek, John W. ;
Eggers, Paul ;
Van Lente, Frederick ;
Greene, Tom ;
Coresh, Josef .
ANNALS OF INTERNAL MEDICINE, 2009, 150 (09) :604-612
[25]   The Essential Element Manganese, Oxidative Stress, and Metabolic Diseases: Links and Interactions [J].
Li, Longman ;
Yang, Xiaobo .
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2018, 2018
[26]   Association between exposure to arsenic, nickel, cadmium, selenium, and zinc and fasting blood glucose levels [J].
Li, Zhaoyang ;
Xu, Yali ;
Huang, Zhijun ;
Wei, Yue ;
Hou, Jian ;
Long, Tengfei ;
Wang, Fei ;
Hu, Hua ;
Duan, Yanying ;
Guo, Huan ;
Zhang, Xiaomin ;
Chen, Xiang ;
Yuan, Hong ;
Wu, Tangchun ;
Shen, Minxue ;
He, Meian .
ENVIRONMENTAL POLLUTION, 2019, 255
[27]   Sex differences, endogenous sex-hormone hormones, sex-hormone binding globulin, and exogenous disruptors in diabetes and related metabolic outcomes [J].
Liu, Simin ;
Sun, Qi .
JOURNAL OF DIABETES, 2018, 10 (06) :428-441
[28]   HOMEOSTASIS MODEL ASSESSMENT - INSULIN RESISTANCE AND BETA-CELL FUNCTION FROM FASTING PLASMA-GLUCOSE AND INSULIN CONCENTRATIONS IN MAN [J].
MATTHEWS, DR ;
HOSKER, JP ;
RUDENSKI, AS ;
NAYLOR, BA ;
TREACHER, DF ;
TURNER, RC .
DIABETOLOGIA, 1985, 28 (07) :412-419
[29]   Evaluation of Mn-superoxide dismutase and catalase gene expression in childhood obesity: its association with insulin resistance [J].
Mohseni, Roohollah ;
Sadeghabadi, Zahra Arab ;
Goodarzi, Mohammad Taghi ;
Teimouri, Maryam ;
Nourbakhsh, Mitra ;
Azar, Maryam Razzaghy .
JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM, 2018, 31 (07) :727-732
[30]   Zinc and Selenium Co-supplementation Reduces Some Lipid Peroxidation and Angiogenesis Markers in a Rat Model of NAFLD-Fed High Fat Diet [J].
Mousavi, Seyedeh Neda ;
Faghihi, Amirhosein ;
Motaghinejad, Majid ;
Shiasi, Maryam ;
Imanparast, Fatemeh ;
Amiri, Hamid Lorvand ;
Shidfar, Farzad .
BIOLOGICAL TRACE ELEMENT RESEARCH, 2018, 181 (02) :288-295