Protective effect of beta-carotene against titanium dioxide nanoparticles induced apoptosis in mouse testicular tissue

被引：10
作者：
Orazizadeh, M. [1 ,2 ]
Daneshi, E. [1 ]
Hashemitmar, M. [1 ,2 ]
Absalan, F. [1 ]
Khorsandi, L. [1 ,2 ]
机构：
[1] Ahvaz Jundishapur Univ Med Sci, Cell & Mol Res Ctr, Ahvaz, Iran
[2] Ahvaz Jundishapur Univ Med Sci, Dept Anat Sci, Ahvaz, Iran
来源：
ANDROLOGIA | 2015年 / 47卷 / 07期
关键词：
Apoptosis; nanomaterials; spermatogenesis; ACTIVATED PROTEIN-KINASE; GERM-CELL APOPTOSIS; BIOCHEMICAL PARAMETERS; SEMEN QUALITY; VITAMIN-E; P38; MAPK; PATHWAY; DEATH; CYTOTOXICITY; ANTIOXIDANT;
D O I：
10.1111/and.12336
中图分类号：
R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
摘要：
In this study, the effects of beta-carotene (BC) on testicular germ cell apoptosis arising from titanium dioxide nanoparticles (NTiO2) have been evaluated. In NTiO2-treated mice, expression of apoptotic related genes including Bid, FasL, caspase-3 and p38MAPK was significantly increased. Measurement apoptosis using TUNEL method showed significant increase in apoptotic index of germ cells in NTiO2-treated mice (P<0.05). TUNEL assessments showed that the increase of apoptotic index of testicular germ cells in NTiO2-treated mice was reversed by BC. Beta-carotene pre-treatment could also effectively attenuate the expression of apoptotic related genes. The application of BC may serve as a beneficial medication to protect germ cells against apoptosis induced by nanoparticles and be helpful for male fertility.
引用
收藏
页码：816 / 825
页数：10
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