Indium(III) Chloride-Catalyzed Propargylation/Amination/Cycloisomerization Tandem Reaction: One-Pot Synthesis of Highly Substituted Pyrroles from Propargylic Alcohols, 1,3-Dicarbonyl Compounds and Primary Amines

被引：79

作者：

Liu, Xiao-tao ^{[1
]}

Huang, Lei ^{[1
]}

Zheng, Fei-jian ^{[1
]}

Zhan, Zhuang-ping ^{[1
]}

机构：

[1] Xiamen Univ, Dept Chem, Coll Chem & Chem Engn, Xiamen 361005, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2008年 / 350卷 / 17期

基金：

中国国家自然科学基金;

关键词：

1,3-dicarbonyl compounds; indium(III) chloride; primary amines; propargylic alcohols; pyrroles; tandem reactions;

D O I：

10.1002/adsc.200800473

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A convenient one-pot propargylation/amination/cycloisomerization tandem process has been developed for the synthesis of highly substituted pyrroles derivatives from propargylic alcohols, 1,3-dicarbonyl compounds and primary amines using indium(III) chloride as a multifunctional catalyst. This method provides a flexible and rapid route to substituted pyrroles.

引用

页码：2778 / 2788

页数：11

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