Molecular Imaging of Chemokine Receptor CXCR4

被引：72

作者：

Weiss, Ido. D. ^{[1
]}

Jacobson, Orit ^{[2
]}

机构：

[1] Hadassah Univ Hosp, Goldyne Savad Inst Gene Therapy, IL-91120 Jerusalem, Israel

[2] Hadassah Hebrew Univ Hosp, Dept Nucl Med, Cyclotron Radiochem Unit, IL-91120 Jerusalem, Israel

来源：

THERANOSTICS | 2013年 / 3卷 / 01期

关键词：

CXCR4; molecular imaging; diagnostics; cancer; HUMAN CANCER XENOGRAFTS; FACTOR-I; EXPRESSION; PET; TUMOR; CELLS; MICROENVIRONMENT; METASTASIS; INHIBITION; ANTAGONIST;

D O I：

10.7150/thno.4835

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

CXCR4 was found to be expressed by many different types of human cancers and its expression has been correlated with tumor aggressiveness, poor prognosis and resistance to chemotherapy. CXCR4 was also shown to contribute to metastatic seeding of organs that express its ligand CXCL12 and support the survival of these cells. These findings suggest that CXCR4 is a potentially attractive therapeutic target, and several antagonists and antibodies for this receptor were developed and are under clinical evaluation. Quantifying CXCR4 expression non-invasively might aid in prognostication as a mean for personalized therapy and post treatment monitoring. Multiple attempts were done over the recent years to develop imaging agents for CXCR4 using different technologies including PET, SPECT, fluorescent and bioluminescence, and will be reviewed in this paper.

引用

页码：76 / 84

页数：9

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