Overview on the recent study of antimicrobial peptides: Origins, functions, relative mechanisms and application

被引：384

作者：

Li, Yanmei ^{[1
,2
]}

Xiang, Qi ^{[1
,2
]}

Zhang, Qihao ^{[1
,2
]}

Huang, Yadong ^{[1
,2
]}

Su, Zhijian ^{[1
,2
]}

机构：

[1] Jinan Univ, Coll Life Sci & Technol, Biopharmaceut Res & Dev Ctr, Guangzhou 510632, Guangdong, Peoples R China

[2] Jinan Univ, Key Lab Biotechnol & Biopharmaceut Guangdong Prov, Guangzhou 510632, Guangdong, Peoples R China

来源：

PEPTIDES | 2012年 / 37卷 / 02期

关键词：

Antimicrobial peptides; Origins; Functions; Mechanisms; Application; ESCHERICHIA-COLI EXPRESSION; CARBOHYDRATE-BINDING-MODULE; ALPHA-HELICAL DOMAIN; ANTIBACTERIAL PEPTIDE; ANTIFUNGAL ACTIVITY; PORE FORMATION; CDNA CLONING; DEFENSIN; INSECT; PURIFICATION;

D O I：

10.1016/j.peptides.2012.07.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Antimicrobial peptides (AMPs), which are produced by several species including insects, other animals, micro-organisms and synthesis, are a critical component of the natural defense system. With the growing problem of pathogenic organisms resistant to conventional antibiotics, especially with the emergence of NDM-1, there is increased interest in the pharmacological application of AMPs. They can protect against a broad array of infectious agents, such as bacteria, fungi, parasite, virus and cancer cells. AMPs have a very good future in the application in pharmaceuticals industry and food additive. This review focuses on the AMPs from different origins in these recent years, and discusses their various functions and relative mechanisms of action. It will provide some detailed files for clinical research of pharmaceuticals industry and food additive in application. (C) 2012 Elsevier Inc. All rights reserved.

引用

页码：207 / 215

页数：9

共 113 条

[41] Armadillidin:: a novel glycine-rich antibacterial peptide directed against gram-positive bacteria in the woodlouse Armadillidium vulgare (Terrestrial Isopod, Crustacean) [J].