Case of neuro-Behcet's disease successfully maintained a remission using infliximab for 2 years

被引:8
作者
Kanemaru, Hisashi [1 ]
Makino, Takamitsu [1 ]
Jinnin, Masatoshi [1 ]
Yonemitsu, Aya [1 ]
Makino, Katsunari [1 ]
Ihn, Hironobu [1 ]
机构
[1] Kumamoto Univ, Fac Life Sci, Dept Dermatol & Plast Surg, Kumamoto 8608556, Japan
关键词
Behcet's disease; infliximab; long-term effects; neuro-Behcet's disease; tumor necrosis factor-; ALPHA; IL-8;
D O I
10.1111/1346-8138.12203
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Behcet's disease is a systemic inflammatory disorder with chronic remissions and relapses. Involvement of the central nervous system, called neuro-Behcet's disease (NBD), is a serious complication. Although corticosteroids and immunosuppressive agents are used, there is no definite standard of treatment with long term-effects for NBD. Here, we report a female case with NBD successfully treated by infliximab and corticosteroids for 2years. Our report suggests treatment with infliximab may be effective for long-term remission of NBD.
引用
收藏
页码:632 / 634
页数:3
相关论文
共 12 条
[1]   Infliximab for patients with neuro-Behcet's disease: case series and literature review [J].
Borhani Haghighi, Afshin ;
Safari, Anahid ;
Nazarinia, Mohammad Ali ;
Habibagahi, Zahra ;
Shenavandeh, Saeedeh .
CLINICAL RHEUMATOLOGY, 2011, 30 (07) :1007-1012
[2]   Serum levels of TNF-α, sIL-2R, IL-6, and IL-8 are increased and associated with elevated lipid peroxidation in patients with Behcet's disease [J].
Evereklioglu, C ;
Er, H ;
Türköz, Y ;
Çekmen, M .
MEDIATORS OF INFLAMMATION, 2002, 11 (02) :87-93
[3]   Infliximab monotherapy in Neuro-Behcet's disease: Four year follow-up in a long-standing case resistant to conventional therapies [J].
Fasano, Alfonso ;
D'Agostino, Magda ;
Caldarola, Giacomo ;
Feliciani, Claudio ;
De Simone, Clara .
JOURNAL OF NEUROIMMUNOLOGY, 2011, 239 (1-2) :105-107
[4]  
Gül A, 2001, CLIN EXP RHEUMATOL, V19, pS6
[5]   EULAR recommendations for the management of Behcet disease [J].
Hatemi, G. ;
Silman, A. ;
Bang, D. ;
Bodaghi, B. ;
Chamberlain, A. M. ;
Gul, A. ;
Houman, M. H. ;
Kotter, I. ;
Olivieri, I. ;
Salvarani, C. ;
Sfikakis, P. P. ;
Siva, A. ;
Stanford, M. R. ;
Stuebiger, N. ;
Yurdakul, S. ;
Yazici, H. .
ANNALS OF THE RHEUMATIC DISEASES, 2008, 67 (12) :1656-1662
[6]   Central nervous system symptoms in patients with Behcet disease receiving cyclosporine therapy [J].
Kotake, S ;
Higashi, K ;
Yoshikawa, K ;
Sasamoto, Y ;
Okamoto, T ;
Matsuda, H .
OPHTHALMOLOGY, 1999, 106 (03) :586-589
[7]  
MEGE JL, 1993, J RHEUMATOL, V20, P1544
[8]   Infliximab for the treatment of neuro-Behcet's disease: A case series and review of the literature [J].
Pipitone, Nicolo ;
Olivieri, Ignazio ;
Padula, Angela ;
D'Angelo, Salvatore ;
Nigro, Angelo ;
Zuccoli, Giulio ;
Boiardi, Luigi ;
Salvarani, Carlo .
ARTHRITIS & RHEUMATISM-ARTHRITIS CARE & RESEARCH, 2008, 59 (02) :285-290
[9]   Infliximab for recurrent, sight-threatening ocular inflammation in Adamantiades-Behcet disease [J].
Sfikakis, PP ;
Kaklamanis, PH ;
Elezoglou, A ;
Katsilambros, N ;
Theodossiadis, PG ;
Papaefthimiou, S ;
Markomichelakis, N .
ANNALS OF INTERNAL MEDICINE, 2004, 140 (05) :404-406
[10]   Behcet's disease: a new target for anti-tumour necrosis factor treatment [J].
Sfikakis, PP .
ANNALS OF THE RHEUMATIC DISEASES, 2002, 61 :51-53