Interaction of 5-amino-1,3,4-thiadiazole-2-thiol and its Violuric Acid Adduct with Pt(II) - Crystals Structures, Spectroscopic Properties and Cytotoxic Activity

被引：4
|
作者：
Kavlakova, M. [1 ]
Bakalova, A. [1 ]
Momekov, G. [2 ]
Ivanov, D. [1 ]
机构：
[1] Med Univ Sofia, Fac Pharm, Dept Chem, Sofia 1000, Bulgaria
[2] Med Univ Sofia, Fac Pharm, Dept Pharmacol Pharmacotherapy & Toxicol, Sofia 1000, Bulgaria
来源：
ARZNEIMITTELFORSCHUNG-DRUG RESEARCH | 2012年 / 62卷 / 12期
关键词：
5-amino-1,3,4-thiadiazole; violurate adduct; Pt (II) complexes; spectroscopic and structural elucidation; cytotoxic activity; N-SUBSTITUTED 2-AMINO-5-(2,4-DIHYDROXYPHENYL)-1,3,4-THIADIAZOLES; GYNECOLOGIC-ONCOLOGY-GROUP; A(3) RECEPTOR ANTAGONISTS; PHASE-II; THIADIAZOLE DERIVATIVES; CELL CARCINOMA; AMINOTHIADIAZOLE; POTENT; AU(III)-COMPLEXES; COMPLEXES;
D O I：
10.1055/s-0032-1327677
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The coordination properties of Pt(II) with 5-amino-1,3,4-thiadiazole-2-thiol [CAS 2349-67-9] (L-1) and its novel violurate adduct (L-2), both in solution and in solid state, are studied by means of conventional IR-spectroscopy, single crystal X-ray diffraction and thermal methods. The complex compounds of L-1 and L-2, with general formulas [Pt(C2H2N3S2)(2)] and [Pt(C6H4N6S2O3)(Cl)] Cl respectively, are obtained. Quantum chemical calculations of the ligands are performed with a view to obtain electronic structure and optical properties of the ligands L-1 and L-2, respectively. The cell viability of the ligands and metal complexes on a panel of human tumor cell lines is evaluated.
引用
收藏
页码：599 / 602
页数：4
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