Interaction of 5-amino-1,3,4-thiadiazole-2-thiol and its Violuric Acid Adduct with Pt(II) - Crystals Structures, Spectroscopic Properties and Cytotoxic Activity

The coordination properties of Pt(II) with 5-amino-1,3,4-thiadiazole-2-thiol [CAS 2349-67-9] (L-1) and its novel violurate adduct (L-2), both in solution and in solid state, are studied by means of conventional IR-spectroscopy, single crystal X-ray diffraction and thermal methods. The complex compounds of L-1 and L-2, with general formulas [Pt(C2H2N3S2)(2)] and [Pt(C6H4N6S2O3)(Cl)] Cl respectively, are obtained. Quantum chemical calculations of the ligands are performed with a view to obtain electronic structure and optical properties of the ligands L-1 and L-2, respectively. The cell viability of the ligands and metal complexes on a panel of human tumor cell lines is evaluated.