The cGAS-STING pathway and cancer

被引：340

作者：

Samson, Natasha ^{[1
]}

Ablasser, Andrea ^{[1
,2
]}

机构：

[1] Swiss Fed Inst Technol Lausanne EPFL, Global Hlth Inst, Lausanne, Switzerland

[2] Swiss Fed Inst Technol EPFL, Swiss Inst Expt Canc Res ISREC, Lausanne, Switzerland

来源：

NATURE CANCER | 2022年 / 3卷 / 12期

基金：

欧洲研究理事会;

关键词：

CYCLIC GMP-AMP; DEPENDENT ANTITUMOR IMMUNITY; CYTOSOLIC DNA SENSOR; I IFN SIGNALS; DENDRITIC CELLS; EXTRACELLULAR CGAMP; INTERFERON RESPONSE; MITOCHONDRIAL-DNA; BYSTANDER CELLS; INNATE IMMUNITY;

D O I：

10.1038/s43018-022-00468-w

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway has emerged as a critical innate immune pathway that, following engagement by DNA, promotes distinct immune effector responses that can impact virtually all aspects of tumorigenesis, from malignant cell transformation to metastasis. Here we address how natural tumor-associated processes and traditional cancer therapies are shaped by cGAS-STING signaling, and how this contributes to beneficial or detrimental outcomes of cancer. We consider current efforts to target the cGAS-STING axis in tumors and highlight new frontiers in cGAS-STING biology to inspire thinking about their connection to cancer.

引用

页码：1452 / 1463

页数：12

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