Simultaneous Determination of Sitagliptin and Metformin in Their Pharmaceutical Formulation

被引：16

作者：

Rezk, Mamdouh R. ^{[1
]}

Riad, Safa'a M. ^{[1
]}

Mahmoud, Ghada Y. ^{[1
]}

Aleem, Abdel-Aziz El Bayoumi Abdel ^{[1
]}

机构：

[1] Cairo Univ, Fac Pharm, Dept Analyt Chem, ET-11562 Cairo, Egypt

来源：

JOURNAL OF AOAC INTERNATIONAL | 2013年 / 96卷 / 02期

关键词：

TANDEM MASS-SPECTROMETRY; PERFORMANCE LIQUID-CHROMATOGRAPHY; SOLID-PHASE EXTRACTION; HUMAN PLASMA; PIOGLITAZONE HYDROCHLORIDE; TABLET FORMULATION; ANTIDIABETIC DRUGS; DOSAGE FORM; HPLC-UV; ROSIGLITAZONE;

D O I：

10.5740/jaoacint.11-383

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Two simple, accurate, and rapid methods were developed for simultaneous determination of sitagliptin phosphate and metformin hydrochloride in their pharmaceutical formulation. The first is a TLC method coupled with densitometry. The second is an HPLC method using a C-18 column. The selectivity of the proposed methods was checked using laboratory-prepared mixtures. The proposed methods were successfully applied to the analysis of sitagliptin phosphate and metformin hydrochloride in bulk form and in their pharmaceutical formulation without interference from other additives.

引用

页码：301 / 306

页数：6

共 43 条

[11]

Gyseghem E., 2005, J CHROMATOGR A, V1074, P117

[12] Near infra-red reflectance spectroscopic determination of metformin in tablets [J].

Habib, IHI ;

Kamel, MS .

TALANTA, 2003, 60 (01) :185-190

[13] Simultaneous identification and validated quantification of 11 oral hypoglycaemic drugs in plasma by electrospray ionisation liquid chromatography-mass spectrometry [J].

Hess, Cornelius ;

Musshoff, Frank ;

Madea, Burkhard .

ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2011, 400 (01) :33-41

[14] Simultaneous estimation of metformin hydrochloride, pioglitazone hydrochloride, and glimepiride by RP-HPLC in tablet formulation [J].

Jain, Deepti ;

Jain, Surendra ;

Jain, Deepak ;

Amin, Maulik .

JOURNAL OF CHROMATOGRAPHIC SCIENCE, 2008, 46 (06) :501-504

[15]

Khan G., 2011, Asian J Biochem and Pharmaceut Res, V1, P352

[16] Simultaneous determination of metformin and glimepride in pharmaceutical dosage form by reverse-phase liquid chromatography [J].

Kolte, BL ;

Raut, BB ;

Deo, AA ;

Bagool, MA ;

Shinde, DB .

JOURNAL OF SEPARATION SCIENCE, 2005, 28 (16) :2076-2079

[17] Simultaneous determination of metformin in combination with rosiglitazone by reversed-phase liquid chromatography [J].

Kolte, BL ;

Raut, BB ;

Deo, AA ;

Bagool, MA ;

Shinde, DB .

JOURNAL OF CHROMATOGRAPHIC SCIENCE, 2004, 42 (02) :70-73

[18]

Kolte BL, 2004, J CHROMATOGR SCI, V42, P27

[19] Simultaneous determination of metformin in its multicomponent dosage forms with glipizide and gliclazide using micellar liquid chromatography [J].

Kolte, BL ;

Raut, BB ;

Deo, AA ;

Bagool, MA ;

Shinde, DB .

JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES, 2003, 26 (07) :1117-1133

[20] Solid phase extraction - Non-aqueous capillary electrophoresis for determination of metformin, phenformin and glyburide in human plasma [J].

Lai, Edward P. C. ;

Feng, Sherry Y. .

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2006, 843 (01) :94-99

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