Longitudinal Analysis of Quality of Life, Clinical, Radiographic, Echocardiographic, and Laboratory Variables in Dogs with Preclinical Myxomatous Mitral Valve Disease Receiving Pimobendan or Placebo: The EPIC Study

被引：58

作者：

Boswood, A. ^{[1
]}

Gordon, S. G. ^{[2
]}

Haggstrom, J. ^{[3
]}

Wess, G. ^{[4
]}

Stepien, R. L. ^{[5
]}

Oyama, M. A. ^{[6
]}

Keene, B. W. ^{[7
]}

Bonagura, J. ^{[8
]}

MacDonald, K. A. ^{[9
]}

Patteson, M. ^{[10
]}

Smith, S. ^{[11
]}

Fox, P. R. ^{[12
]}

Sanderson, K. ^{[13
]}

Woolley, R. ^{[14
]}

Szatmari, V. ^{[15
]}

Menaut, P. ^{[16
]}

Church, W. M. ^{[17
]}

O'Sullivan, M. L. ^{[18
]}

Jaudon, J. -P. ^{[19
]}

Kresken, J. -G. ^{[20
]}

Rush, J. ^{[21
]}

Barrett, K. A. ^{[22
]}

Rosenthal, S. L. ^{[23
]}

Saunders, A. B. ^{[2
]}

Ljungvall, I. ^{[3
]}

Deinert, M. ^{[24
]}

Bomassi, E. ^{[25
]}

Estrada, A. H. ^{[26
]}

Fernandez Del Palacio, M. J. ^{[27
]}

Moise, N. S. ^{[28
]}

Abbott, J. A. ^{[29
]}

Fujii, Y. ^{[30
]}

Spier, A. ^{[31
]}

Luethy, M. W. ^{[32
]}

Santilli, R. A. ^{[33
]}

Uechi, M. ^{[34
]}

Tidholm, A. ^{[35
]}

Schummer, C. ^{[36
]}

Watson, P. ^{[36
]}

机构：

[1] Royal Vet Coll, Dept Vet Clin Sci, Hatfield, Herts, England

[2] Texas A&M Univ, Small Anim Clin Sci, College Stn, TX USA

[3] Swedish Univ Agr Sci, Dept Clin Sci, Uppsala, Sweden

[4] Univ Munich, Clin Small Anim Med, Munich, Germany

[5] Univ Wisconsin, Sch Vet Med, Med Sci, Madison, WI 53706 USA

[6] Univ Penn, MJR VHUP Cardiol, Clin Studies Philadelphia, Philadelphia, PA 19104 USA

[7] North Carolina State Univ, Coll Vet Med, Dept Clin Sci, Raleigh, NC USA

[8] Ohio State Univ, Dept Vet Clin Sci, Columbus, OH 43210 USA

[9] Anim Care Ctr, Rohnert Pk, CA USA

[10] Anim Hosp, HeartVets Vale Referrals, Dursley, Glos, England

[11] Sarah Smith Cardiol, Derby, England

[12] Anim Med Ctr, New York, NY USA

[13] Rocky Mt Vet Cardiol, Boulder, CO USA

[14] Cardio Resp Pet Referrals Victoria, Mordialloc, Vic, Australia

[15] Univ Utrecht, Fac Med Vet, Clin Sci Compan Animals, Utrecht, Netherlands

[16] Ctr Vet Aquivet, Internal Med & Cardiol, Eysines, France

[17] Desert Vet Med Specialists, Phoenix, AZ USA

[18] Univ Guelph, Ontario Vet Coll, Dept Clin Studies, Guelph, ON, Canada

[19] Clin Vet Etangs, Villars Les Dombes, France

[20] Clin Small Anim Kaiserberg, Duisburg, Germany

[21] Tufts Univ, Cummings Sch Vet Med, Clin Sci, North Grafton, MA USA

[22] VCA West Los Angeles, Cardiol, Los Angeles, CA USA

[23] CVCA Cardiac Care Pets, Towson, MD USA

[24] Tierklin Sandpfad, Wiesloch, Germany

[25] Ctr Hosp Vet Cordeliers, Cardiol, Meaux, France

[26] Univ Florida, Coll Vet Med, Small Anim Clin Sci, Gainesville, FL USA

[27] Univ Murcia, Med & Cirug Anim, Murcia, Spain

[28] Cornell Univ, Coll Vet Med, Clin Sci, Ithaca, NY 14853 USA

[29] Virginia Tech, Virginia Maryland Coll Vet Med, Dept Small Anim Clin Sci, Blacksburg, VA USA

[30] Azabu Univ, Surg 1, Sagamihara, Kanagawa, Japan

[31] Blue Pearl Vet Partners, Tampa, FL USA

[32] Chicago Vet Emergency & Specialty Ctr, Chicago, IL USA

[33] Clin Vet Malpensa, Cardiol, Gallarate, Varese, Italy

[34] Japan Anim Specialty Med Inst Inc, JASMINE Vet Cardiovasc Med Ctr, Yokohama, Kanagawa, Japan

[35] Djursjukhuset Albano, Danderyd, Sweden

[36] Boehringer Ingelheim GmbH & Co KG, Anim Hlth, Ingelheim, Germany

来源：

JOURNAL OF VETERINARY INTERNAL MEDICINE | 2018年 / 32卷 / 01期

关键词：

Cardiology; Cardiovascular; Echocardiography; Endocardiosis; Heart Failure; Mitral regurgitation; CONGESTIVE-HEART-FAILURE; DILATED CARDIOMYOPATHY; NATRIURETIC PEPTIDE; SIZE; REGURGITATION; BENAZEPRIL; CONTRACTILITY; PRESSURE; EFFICACY; INDEXES;

D O I：

10.1111/jvim.14885

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Background: Changes in clinical variables associated with the administration of pimobendan to dogs with preclinical myxomatous mitral valve disease (MMVD) and cardiomegaly have not been described. Objectives: To investigate the effect of pimobendan on clinical variables and the relationship between a change in heart size and the time to congestive heart failure (CHF) or cardiac-related death (CRD) in dogs with MMVD and cardiomegaly. To determine whether pimobendan-treated dogs differ from dogs receiving placebo at onset of CHF. Animals: Three hundred and fifty-four dogs with MMVD and cardiomegaly. Materials and Methods: Prospective, blinded study with dogs randomized (ratio 1:1) to pimobendan (0.4-0.6 mg/kg/d) or placebo. Clinical, laboratory, and heart-size variables in both groups were measured and compared at different time points (day 35 and onset of CHF) and over the study duration. Relationships between short-term changes in echocardiographic variables and time to CHF or CRD were explored. Results: At day 35, heart size had reduced in the pimobendan group: median change in (D) LVIDDN -0.06 (IQR: -0.15 to +0.02), P < 0.0001, and LA: Ao -0.08 (IQR: -0.23 to +0.03), P < 0.0001. Reduction in heart size was associated with increased time to CHF or CRD. Hazard ratio for a 0.1 increase in DLVIDDN was 1.26, P - 0.0003. Hazard ratio for a 0.1 increase in DLA: Ao was 1.14, P = 0.0002. At onset of CHF, groups were similar. Conclusions and Clinical Importance: Pimobendan treatment reduces heart size. Reduced heart size is associated with improved outcome. At the onset of CHF, dogs treated with pimobendan were indistinguishable from those receiving placebo.

引用

页码：72 / 85

页数：14

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