7-methoxyfuro[2,3-c]pyridine-4-carboxamides as PDE4 inhibitors:: A potential treatment for asthma

被引：20

作者：

Buckley, GM ^{[1
]}

Cooper, N ^{[1
]}

Davenport, RJ ^{[1
]}

Dyke, HJ ^{[1
]}

Galleway, FP ^{[1
]}

Gowers, L ^{[1
]}

Haughan, AF ^{[1
]}

Kendall, HJ ^{[1
]}

Lowe, C ^{[1
]}

Montana, JG ^{[1
]}

Oxford, J ^{[1
]}

Peake, JC ^{[1
]}

Picken, CL ^{[1
]}

Richard, MD ^{[1
]}

Sabin, V ^{[1
]}

Sharpe, A ^{[1
]}

Warneck, JBH ^{[1
]}

机构：

[1] Celltech R&D, Cambridge CB1 6GS, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 03期

关键词：

D O I：

10.1016/S0960-894X(01)00786-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis and pharmacological profile of a novel series of 7-methoxy-furo[2,3-c]pyridine-4-carboxamides is described. Some of these compounds were found to be potent inhibitors of phosphodiesterase type 4 (PDE4). Initial (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：509 / 512

页数：4

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