Polymorphic Transporters and Platinum Pharmacodynamics

被引:54
作者
Sprowl, Jason A. [1 ]
Ness, Rachel A. [1 ]
Sparreboom, Alex [1 ]
机构
[1] St Jude Childrens Res Hosp, Dept Pharmaceut Sci, Memphis, TN 38105 USA
基金
美国国家卫生研究院;
关键词
solute carriers; cisplatin; carboplatin; oxaliplatin; drug disposition; SNPs; pharmacodynamics; ORGANIC CATION TRANSPORTERS; CISPLATIN-INDUCED NEPHROTOXICITY; CELL LUNG-CANCER; ADENOSINE-TRIPHOSPHATASE ATP7B; MULTIDRUG-RESISTANCE PROTEIN; TOXIN EXTRUSION MATE1; COPPER TRANSPORTER; ANION TRANSPORTER; HUMAN-KIDNEY; GENETIC POLYMORPHISMS;
D O I
10.2133/dmpk.DMPK-12-RV-073
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Several solute carriers and ATP-binding cassette transporters have been implicated in the influx or efflux of platinum-based chemotherapeutic agents such as cisplatin, carboplatin, and oxaliplatin. Given that many of these proteins are highly polymorphic, the genetic status of these proteins could be an important contributor to the extensive interindividual pharmacokinetic variability associated with the clinical use of these agents. In this review article, we provide an updated overview of the various transporters that have shown promise in animal models or patient populations in facilitating the movement of platinum-based agents across cell membranes, and how their function is associated with drug disposition or pharmacodynamic effects.
引用
收藏
页码:19 / 27
页数:9
相关论文
共 128 条
[1]   Renal xenobiotic transporters are differentially expressed in mice following cisplatin treatment [J].
Aleksunes, Lauren M. ;
Augustine, Lisa M. ;
Scheffer, George L. ;
Cherrington, Nathan J. ;
Manautou, Jose E. .
TOXICOLOGY, 2008, 250 (2-3) :82-88
[2]   Tissue distribution and ontogeny of organic cation transporters in mice [J].
Alnouti, Y ;
Petrick, JS ;
Klaassen, CD .
DRUG METABOLISM AND DISPOSITION, 2006, 34 (03) :477-482
[3]   Cisplatin-versus carboplatin-based chemotherapy in first-line treatment of advanced non-small-cell lung cancer: An individual patient data meta-analysis [J].
Ardizzoni, Andrea ;
Boni, Luca ;
Tiseo, Marcello ;
Fossella, Frank V. ;
Schiller, Joan H. ;
Paesmans, Marianne ;
Radosavljevic, Davorin ;
Paccagnella, Adriano ;
Zatloukal, Petr ;
Mazzanti, Paola ;
Bisset, Donald ;
Rosell, Rafael .
JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2007, 99 (11) :847-857
[4]   NEPHROTOXICITY MECHANISM OF CISPLATINUM (II) DIAMINE DICHLORIDE IN MICE [J].
BAN, M ;
HETTICH, D ;
HUGUET, N .
TOXICOLOGY LETTERS, 1994, 71 (02) :161-168
[5]   Increased levels and defective glycosylation of MRPs in ovarian carcinoma cells resistant to oxaliplatin [J].
Beretta, Giovanni Luca ;
Benedetti, Valentina ;
Cossa, Giacomo ;
Assaraf, Yehuda G. A. ;
Bram, Eran ;
Gatti, Laura ;
Corna, Elisabetta ;
Carenini, Nives ;
Colangelo, Donato ;
Howell, Stephen B. ;
Zunino, Franco ;
Perego, Paola .
BIOCHEMICAL PHARMACOLOGY, 2010, 79 (08) :1108-1117
[6]   KINETICS AND MECHANISM OF UPTAKE OF PLATINUM-BASED PHARMACEUTICALS BY THE RAT SMALL-INTESTINE [J].
BINKS, SP ;
DOBROTA, M .
BIOCHEMICAL PHARMACOLOGY, 1990, 40 (06) :1329-1336
[7]   Copper Transporter 2 Regulates the Cellular Accumulation and Cytotoxicity of Cisplatin and Carboplatin [J].
Blair, Brian G. ;
Larson, ChristopherA. ;
Safaei, Roohangiz ;
Howell, Stephen B. .
CLINICAL CANCER RESEARCH, 2009, 15 (13) :4312-4321
[8]  
Boiarskikh U A, 2011, Mol Biol (Mosk), V45, P652
[9]   Differential transport of platinum compounds by the human organic cation transporter hOCT2 (hSLC22A2) [J].
Burger, H. ;
Zoumaro-Djayoon, A. ;
Boersma, A. W. M. ;
Helleman, J. ;
Berns, E. M. J. J. ;
Mathijssen, R. H. J. ;
Loos, W. J. ;
Wiemer, E. A. C. .
BRITISH JOURNAL OF PHARMACOLOGY, 2010, 159 (04) :898-908
[10]  
Chitapanarux I, 2010, Biomed Imaging Interv J, V6, pe23, DOI 10.2349/biij.6.3.e23