Genetic and biochemical characterisation of OXA-232, a carbapenem-hydrolysing class D β-lactamase from Enterobacteriaceae

被引：144

作者：

Potron, Anais ^{[1
,2
]}

Rondinaud, Emilie ^{[1
,2
]}

Poirel, Laurent ^{[1
,2
]}

Belmonte, Olivier ^{[3
]}

Boyer, Sophie ^{[4
]}

Camiade, Sabine ^{[5
]}

Nordmann, Patrice ^{[1
,2
]}

机构：

[1] Hop Bicetre, AP HP, Serv Bacteriol Virol, INSERM,Fac Med,Emerging Resistance Antiobiot U914, K Bicetre, France

[2] Univ Paris 11, K Bicetre, France

[3] CHR Felix Guyon, St Denis, Reunion, France

[4] Lab Novescia, Wissous, France

[5] Lab Alphabio, Marseille, France

来源：

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS | 2013年 / 41卷 / 04期

关键词：

Resistance; Carbapenems; Class D beta-lactamase; Enterobacteriaceae; OXA-232; KLEBSIELLA-PNEUMONIAE; OXA-48-LIKE CARBAPENEMASES; EMERGENCE; RESISTANCE; SPREAD; PCR;

D O I：

10.1016/j.ijantimicag.2012.11.007

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Three enterobacterial isolates (two Klebsiella pneumoniae and one Escherichia coli) were recovered from three patients transferred from India to France in 2011. All three isolates were resistant or of intermediate susceptibility to all beta-lactams and of decreased susceptibility to carbapenems. These three isolates expressed a novel carbapenem-hydrolysing beta-lactamase, OXA-232, differing from OXA-181 and OXA-48 by one and five amino acid substitutions, respectively. Compared with OXA-181, OXA-232 had a lower ability to hydrolyse carbapenems but conversely possessed higher hydrolytic activities against penicillins. The bla(OXA-232) gene was located on a 6.1-kb ColE-type non-conjugative plasmid. (C) 2012 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.

引用

页码：325 / 329

页数：5

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