Digital ulcers: should debridement be a standard of care in systemic sclerosis?

被引:11
作者
Hughes, Michael [1 ,2 ]
Alcacer-Pitarch, Begonya [3 ,4 ]
Allanore, Yannick [5 ]
Baron, Murray [6 ]
Boin, Francesco [7 ]
Bruni, Cosimo [8 ]
Chung, Lorinda [9 ,10 ]
Del Galdo, Francesco [3 ,4 ]
Denton, Christopher P. [11 ]
Matucci-Cerinic, Marco [8 ]
机构
[1] Sheffield Teaching Hosp NHS Fdn Trust, Royal Hallamshire Hosp, Dept Rheumatol, Sheffield S10 2JF, S Yorkshire, England
[2] Univ Manchester, Ctr Musculoskeletal Res, Fac Biol Med & Hlth, Manchester, Lancs, England
[3] Univ Leeds, Leeds Inst Rheumat & Musculoskeletal Med, Leeds, W Yorkshire, England
[4] Leeds Teaching Hosp NHS Trust, NIHR Biomed Res Ctr, Leeds, W Yorkshire, England
[5] Paris Descartes Univ, Cochin Hosp, AP HP, Dept Rheumatol, Paris, France
[6] McGill Univ, Div Rheumatol, Dept Med, Montreal, PQ, Canada
[7] Univ Calif San Francisco, Dept Med, Div Rheumatol, San Francisco, CA 94143 USA
[8] Univ Florence, Div Rheumatol, Dept Expt & Clin Med, Florence, Italy
[9] Stanford Univ, Sch Med, Dept Med, Div Rheumatol & Immunol, Palo Alto, CA 94304 USA
[10] Palo Alto VA Hlth Care Syst, Palo Alto, CA USA
[11] UCL, Royal Free Hosp, Dept Rheumatol, London, England
关键词
DOUBLE-BLIND; RAYNAUDS-PHENOMENON; DISEASE; MULTICENTER; SILDENAFIL; MANAGEMENT; BOSENTAN; EFFICACY; THERAPY; IMPACT;
D O I
10.1016/S2665-9913(19)30164-X
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Digital ulcers are a serious, recurrent complication in patients with systemic sclerosis. They are often slow to heal and exquisitely painful. Local wound care, such as debridement of the wound bed, is an essential component in the management of digital ulcers in systemic sclerosis. However, digital ulcer debridement is not a standard of care, and there is substantial international variation in the use of this approach. In this Viewpoint, we discuss the assessment of the wound bed and different methods of debridement using the model of tissue management, infection and inflammation, moisture control, and wound edge or epidermal advancement, known as TIME. We highlight the challenges in standard practice and the need for research into local wound care for this type of ulceration, before suggesting a potential roadmap to develop a standardised approach to support ulcer debridement in systemic sclerosis. Debridement might be the missing component in optimising the management of digital ulcers and we propose that the approach should be rigorously investigated as a standard of care in this common complication of systemic sclerosis.
引用
收藏
页码:E302 / E307
页数:6
相关论文
共 48 条
[1]   Digital ulcers in scleroderma: staging, characteristics and sub-setting through observation of 1614 digital lesions [J].
Amanzi, Laura ;
Braschi, Francesca ;
Fiori, Ginevra ;
Galluccio, Felice ;
Miniati, Irene ;
Guiducci, Serena ;
Conforti, Maria-Letizia ;
Kaloudi, Olga ;
Nacci, Francesca ;
Sacu, Oana ;
Candelieri, Antonio ;
Pignone, Alberto ;
Rasero, Laura ;
Conforti, Domenico ;
Matucci-Cerinic, Marco .
RHEUMATOLOGY, 2010, 49 (07) :1374-1382
[2]  
[Anonymous], 2015, COCHRANE DATABASE SY
[3]   Consensus opinion of a North American Working Group regarding the classification of digital ulcers in systemic sclerosis [J].
Baron, Murray ;
Chung, Lorinda ;
Gyger, Genevieve ;
Hummers, Laura ;
Khanna, Dinesh ;
Mayes, Maureen D. ;
Pope, Janet E. ;
Shah, Ami A. ;
Steen, Virginia D. ;
Steele, Russell ;
Tatibouet, Solene ;
Herrick, Ariane ;
Mueller-Ladner, Ulf ;
Hudson, Marie .
CLINICAL RHEUMATOLOGY, 2014, 33 (02) :207-214
[4]   The Therapeutic Efficacy of Botulinum Toxin in Treating Scleroderma-Associated Raynaud's Phenomenon A Randomized, Double-Blind, Placebo-Controlled Clinical Trial [J].
Bello, Ricardo J. ;
Cooney, Carisa M. ;
Melamed, Eitan ;
Follmar, Keith ;
Yenokyan, Gayane ;
Leatherman, Gwendolyn ;
Shah, Ami A. ;
Wigley, Fredrick M. ;
Hummers, Laura K. ;
Lifchez, Scott D. .
ARTHRITIS & RHEUMATOLOGY, 2017, 69 (08) :1661-1669
[5]   Impact of Systemic Sclerosis on Occupational and Professional Activity With Attention to Patients With Digital Ulcers [J].
Berezne, A. ;
Seror, R. ;
Morell-Dubois, S. ;
de Menthon, M. ;
Fois, E. ;
Dzeing-Ella, A. ;
Nguyen, C. ;
Hachulla, E. ;
Guillevin, L. ;
Poiraudeau, S. ;
Mouthon, L. .
ARTHRITIS CARE & RESEARCH, 2011, 63 (02) :277-285
[6]  
Blagojevic J, 2019, ATLAS ULCERS SYSTEMI, P15
[7]   Lidocaine controls pain and allows safe wound bed preparation and debridement of digital ulcers in systemic sclerosis: a retrospective study [J].
Braschi, Francesca ;
Bartoli, Francesca ;
Bruni, Cosimo ;
Fiori, Ginevra ;
Fantauzzo, Claudia ;
Paganelli, Lucia ;
De Paulis, Amato ;
Rasero, Laura ;
Matucci-Cerinic, M. .
CLINICAL RHEUMATOLOGY, 2017, 36 (01) :209-212
[8]   Digital ulcers as a sentinel sign for early internal organ involvement in very early systemic sclerosis [J].
Bruni, Cosimo ;
Guiducci, Serena ;
Bellando-Randone, Silvia ;
Lepri, Gemma ;
Braschi, Francesca ;
Fiori, Ginevra ;
Bartoli, Francesca ;
Peruzzi, Francesca ;
Blagojevic, Jelena ;
Matucci-Cerinic, Marco .
RHEUMATOLOGY, 2015, 54 (01) :72-76
[9]   LAUDES Study: impact of digital ulcers on hand functional limitation, work productivity and daily activities, in systemic sclerosis patients [J].
Castellvi, Ivan ;
Eguiluz, Saioa ;
Escudero-Contreras, Alejandro ;
Jose Rios, Juan ;
Calvo-Alen, Jaime ;
Luis Callejas-Rubio, Jose ;
De la Puente, Carlos ;
Pilar Simeon, Carmen ;
Javier Narvaez, Francisco ;
Espinosa, Gerard ;
Carreira, Patricia E. ;
Rubio-Rivas, Manuel ;
Jose Alegre, Juan ;
Guillen-Del-Castillo, Alfredo ;
Andres Roman-Ivorra, Jose ;
Fonollosa, Vicent ;
Aspe de la Iglesia, Bruno ;
Barbado Ajo, Julia ;
Batista Perdomo, Daniel ;
Beltran Catalan, Emma ;
Belzunegui Otano, Joaquim ;
Blanco Rodriguez, Jorge Santiago ;
Caamano Freire, Manuel ;
Cantabrana Alutiz, Alberto ;
Carrio Montes, Isabel ;
Cia Lecumberri, Maite ;
Del Castillo Monsalvo, Rosa ;
Diez Alvarez, Elvira ;
Egues Dubuc, Cesar Antonio ;
Egurbide Arberas, Maria Victoria ;
Egurbide Arberas, Maria Victoria ;
Fanlo Mateo, Patricia ;
Freire Dapena, Maria Del Carmen ;
Freire Gonzalez, Mercedes ;
Garcia Aparicio, Angel ;
Garcia Hernandez, Francisco Jose ;
Gomez de Salazar, Jose ;
Gonzalez Nieto, Jose Antonio ;
Grana Gil, Jenaro ;
Guillen-Del-Castillo, Alfredo ;
Izquierdo Hidalgo, Jose ;
Juan Mas, Toni ;
Laino Pineiro, Maria Cruz ;
Lopez Longo, Francisco Javier ;
Lopez Nunez, Lilian Maria ;
Marin Ballve, Adela ;
Marras Fernandez-Cid, Carlos ;
Miguelez, Roberto ;
Moran Rodriguez, Miguel Angel ;
Moreno Morales, Juan .
RHEUMATOLOGY INTERNATIONAL, 2019, 39 (11) :1875-1882
[10]   The social costs of digital ulcer management in sclerodema patients: An observational Italian pilot study [J].
Cozzi, Franco ;
Tiso, Francesco ;
Lopatriello, Stefania ;
Ciprian, Luca ;
Sfriso, Paolo ;
Berto, Patrizia ;
Punzi, Leonardo .
JOINT BONE SPINE, 2010, 77 (01) :83-84