ECHINOCANDIN AND ETHANOL LOCK THERAPY TREATMENT OF FUNGAL CATHETER INFECTIONS

被引：14
作者：
Pieroni, Kevin P. [1 ]
Nespor, Colleen [2 ]
Poole, Robert L. [2 ,3 ]
Kerner, John A., Jr. [1 ,2 ]
Berquist, William E. [1 ]
机构：
[1] Stanford Univ, Sch Med, Div Gastroenterol Hepatol & Nutr, Dept Pediat, Palo Alto, CA 94304 USA
[2] Childrens Home Pharm, Palo Alto, CA USA
[3] Lucile Packard Childrens Hosp Stanford, Dept Pharm, Palo Alto, CA 94304 USA
来源：
PEDIATRIC INFECTIOUS DISEASE JOURNAL | 2013年 / 32卷 / 03期
关键词：
ethanol locks; catheter infection; fungal infections; BLOOD-STREAM INFECTIONS; PARENTERAL-NUTRITION PATIENTS; CANDIDA-ALBICANS BIOFILMS; INTESTINAL FAILURE; PEDIATRIC-PATIENTS; ANTIFUNGAL AGENTS; EFFICACY; REDUCE;
D O I：
10.1097/INF.0b013e3182784867
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Ethanol lock therapy has been implemented to prevent infections of central venous catheters as well as to treat infections. Fungal catheter-associated blood stream infections are historically more difficult to treat and have required removal of central venous catheters. We report the largest case series to date, successfully treating 5 of 7 fungal catheter-associated blood stream infections with ethanol lock therapy and systemic echinocandin administration.
引用
收藏
页码：289 / 291
页数：3
相关论文
共 17 条
[1]   In vitro activity of caspofungin against Candida albicans biofilms [J].
Bachmann, SP ;
VandeWalle, K ;
Ramage, G ;
Patterson, TF ;
Wickes, BL ;
Graybill, JR ;
López-Ribot, JL .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2002, 46 (11) :3591-3596
[2]   ETHANOL LOCKS THERAPY FOR RESOLUTION OF FUNGAL CATHETER INFECTIONS [J].
Blackwood, Roland Alexander ;
Klein, Kristin C. ;
Micel, Lindsey N. ;
Willers, Michelle L. ;
Mody, Rajen J. ;
Teitelbaum, Daniel H. ;
Cober, M. Petrea .
PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2011, 30 (12) :1105-1107
[3]   Treatment of central venous catheter fungal infection using liposomal amphotericin-B lock therapy [J].
Buckler, Bradley S. ;
Sams, Ralph N. ;
Goei, Vita L. ;
Krishnan, Karthik R. ;
Bemis, Marci J. ;
Parker, Deidrea P. ;
Murray, Dennis L. .
PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2008, 27 (08) :762-764
[4]   Ethanol disinfection of plastic-adherent micro-organisms [J].
Chambers, S. T. ;
Peddie, B. ;
Pithie, A. .
JOURNAL OF HOSPITAL INFECTION, 2006, 63 (02) :193-196
[5]   Biofilms and their role in the resistance of pathogenic Candida to antifungal agents [J].
d'Enfert, C .
CURRENT DRUG TARGETS, 2006, 7 (04) :465-470
[6]   Efficacy of ethanol locks in reducing central venous catheter infections in pediatric patients with intestinal failure [J].
Jones, Brian A. ;
Hull, Melissa A. ;
Richardson, Denise S. ;
Zurakowski, David ;
Gura, Kathleen ;
Fitzgibbons, Shimae C. ;
Duro, Debora ;
Lo, Clifford W. ;
Duggan, Christopher ;
Jaksic, Tom .
JOURNAL OF PEDIATRIC SURGERY, 2010, 45 (06) :1287-1293
[7]   Antifungal susceptibility of Candida biofilms:: Unique efficacy of amphotericin B lipid formulations and echinocandins [J].
Kuhn, DM ;
George, T ;
Chandra, J ;
Mukherjee, PK ;
Ghannoum, MA .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2002, 46 (06) :1773-1780
[8]   Clinical Practice Guidelines for the Diagnosis and Management of Intravascular Catheter-Related Infection: 2009 Update by the Infectious Diseases Society of America [J].
Mermel, Leonard A. ;
Allon, Michael ;
Bouza, Emilio ;
Craven, Donald E. ;
Flynn, Patricia ;
O'Grady, Naomi P. ;
Raad, Issam I. ;
Rijnders, Bart J. A. ;
Sherertz, Robert J. ;
Warren, David K. .
CLINICAL INFECTIOUS DISEASES, 2009, 49 (01) :1-45
[9]   Use of ethanol locks to prevent recurrent central line sepsis [J].
Metcalf, SCL ;
Chambers, ST ;
Pithie, AD .
JOURNAL OF INFECTION, 2004, 49 (01) :20-22
[10]   Use of an ethanol lock to prevent catheter-related infections in children with short bowel syndrome [J].
Mouw, Etisabeth ;
Chessman, Katherine ;
Lesher, Aaron ;
Tagge, Edward .
JOURNAL OF PEDIATRIC SURGERY, 2008, 43 (06) :1025-1029
12