Antimicrobial peptides: Clinical relevance and therapeutic implications

被引：118

作者：

da Silva, Fabiano Pinheiro ^{[1
]}

Cesar Machado, Marcel Cerqueira ^{[1
]}

机构：

[1] Univ Sao Paulo, Fac Med, Dept Emergency Med, Lab Emergencias Med, BR-01246903 Sao Paulo, Brazil

来源：

PEPTIDES | 2012年 / 36卷 / 02期

基金：

巴西圣保罗研究基金会;

关键词：

Cathelicidins; Defensins; Vitamin D; Autoimmunity; Infection and cancer; TOLL-LIKE RECEPTOR; INVASIVE BACTERIAL-INFECTION; HUMAN CATHELICIDIN LL-37; HOST-DEFENSE SYSTEM; VITAMIN-D; DENDRITIC CELLS; INNATE IMMUNITY; BETA-DEFENSINS; EPITHELIAL-CELLS; GENE-EXPRESSION;

D O I：

10.1016/j.peptides.2012.05.014

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Antimicrobial peptides (AMPS) are molecules that provide protection against environmental pathogens, acting against a large number of microorganisms, including bacteria, fungi, yeast, virus and others. Two major groups of antimicrobial peptides are found in humans: cathelicidins and defensins. Recently, several studies have furnished information that besides their role in infection diseases, antimicrobial peptides play a role in diseases as diverse as inflammatory disorders, autoimmunity and cancer. Here, we discuss the role of antimicrobial peptides and vitamin D have in such complex diseases and propose their use should be more explored in the diagnosis and treatment of such conditions. (C) 2012 Elsevier Inc. All rights reserved.

引用

页码：308 / 314

页数：7

共 90 条

[1] Circulating 25-Hydroxyvitamin D and Risk of Esophageal and Gastric Cancer [J].

Abnet, Christian C. ;

Chen, Yu ;

Chow, Wong-Ho ;

Gao, Yu-Tang ;

Helzlsouer, Kathy J. ;

Le Marchand, Loic ;

McCullough, Marjorie L. ;

Shikany, James M. ;

Virtamo, Jarmo ;

Weinstein, Stephanie J. ;

Xiang, Yong-Bing ;

Yu, Kai ;

Zheng, Wei ;

Albanes, Demetrius ;

Arslan, Alan A. ;

Campbell, David S. ;

Campbell, Peter T. ;

Hayes, Richard B. ;

Horst, Ronald L. ;

Kolonel, Laurence N. ;

Nomura, Abraham M. Y. ;

Purdue, Mark P. ;

Snyder, Kirk ;

Shu, Xiao-Ou .

AMERICAN JOURNAL OF EPIDEMIOLOGY, 2010, 172 (01) :94-106

[2] The Role of Potassium in Inflammasome Activation by Bacteria [J].

Arlehamn, Cecilia S. Lindestam ;

Petrilli, Virginie ;

Gross, Olaf ;

Tschopp, Juerg ;

Evans, Tom J. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (14) :10508-10518

[3] Vitamin D and Breast Cancer [J].

Bertone-Johnson, Elizabeth R. .

ANNALS OF EPIDEMIOLOGY, 2009, 19 (07) :462-467

[4] Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis [J].

Bevins, Charles L. ;

Salzman, Nita H. .

NATURE REVIEWS MICROBIOLOGY, 2011, 9 (05) :356-368

[5] SPECIFIC HIGH-AFFINITY RECEPTORS FOR 1,25-DIHYDROXYVITAMIN-D3 IN HUMAN PERIPHERAL-BLOOD MONONUCLEAR-CELLS - PRESENCE IN MONOCYTES AND INDUCTION IN LYMPHOCYTES-T FOLLOWING ACTIVATION [J].

BHALLA, AK ;

AMENTO, EP ;

CLEMENS, TL ;

HOLICK, MF ;

KRANE, SM .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1983, 57 (06) :1308-1310

[6] Mediators of innate immunity that target immature, but not mature, dendritic cells induce antitumor immunity when genetically fused with nonimmunogenic tumor antigens [J].

Biragyn, A ;

Surenhu, M ;

Yang, D ;

Ruffini, PA ;

Haines, BA ;

Klyushnenkova, E ;

Oppenheim, JJ ;

Kwak, LW .

JOURNAL OF IMMUNOLOGY, 2001, 167 (11) :6644-6653

[7] The human cationic peptide LL-37 induces activation of the extracellular signal-regulated kinase and p38 kinase pathways in primary human monocytes [J].

Bowdish, DME ;

Davidson, DJ ;

Speert, DP ;

Hancock, REW .

JOURNAL OF IMMUNOLOGY, 2004, 172 (06) :3758-3765

[8] Structure-function relationships among human cathelicidin peptides: Dissociation of antimicrobial properties from host immunostimulatory activities [J].

Braff, MH ;

Hawkins, MA ;

Di Nardo, A ;

Lopez-Garcia, B ;

Howell, MD ;

Wong, C ;

Lin, K ;

Streib, JE ;

Dorschner, R ;

Leung, DYM ;

Gallo, RL .

JOURNAL OF IMMUNOLOGY, 2005, 174 (07) :4271-4278

[9]

BROEKAERT WF, 1995, PLANT PHYSIOL, V108, P1353, DOI [10.1016/j.biortech.2014.10.140, 10.1016/j.envsoft.2012.10.004, 10.1016/j.eclinm.2021.100771, 10.1016/j.tourman.2012.10.007, 10.1016/j.coelec.2021.100721, 10.1016/j.jaap.2012.10.004, 10.1016/j.carres.2021.108368, 10.1016/j.chiabu.2021.105188]

[10] The Host Defense Peptide Cathelicidin Is Required for NK Cell-Mediated Suppression of Tumor Growth [J].

Buechau, Amanda S. ;

Morizane, Shin ;

Trowbridge, Janet ;

Schauber, Juergen ;

Kotol, Paul ;

Bui, Jack D. ;

Gallo, Richard L. .

JOURNAL OF IMMUNOLOGY, 2010, 184 (01) :369-378

← 1 2 3 4 5 6 7 8 9 →