A robust treatment of a dose-response study

被引：0
|
作者：
Wiens, Douglas P. [1 ]
Li, Pengfei [1 ]
机构：
[1] Univ Alberta, Dept Math & Stat Sci, Edmonton, AB T6G 2G1, Canada
来源：
APPLIED STOCHASTIC MODELS IN BUSINESS AND INDUSTRY | 2012年 / 28卷 / 02期
基金：
加拿大自然科学与工程研究理事会;
关键词：
Anderson-Darling distance; discrimination; logistic; Neyman-Pearson test; probit; quadratic programming; simulated annealing; OPTIMAL DESIGNS;
D O I：
10.1002/asmb.917
中图分类号：
C93 [管理学]; O22 [运筹学];
学科分类号：
070105 ; 12 ; 1201 ; 1202 ; 120202 ;
摘要：
We give a description of the steps leading to a robustification of a doseresponse study. The original experiment was designed and described by Rosenberger and Grill (1997) and has since been discussed by several other groups of researchers. Our robustification consists of redesigning the experiment so as to build in flexibility over a range of possible link functions, including the logistic link assumed by the original experimenters. We consider as well an asymptotic NeymanPearson test of the validity of the assumed link function.Copyright (c) 2011 John Wiley & Sons, Ltd.
引用
收藏
页码：164 / 173
页数：10
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