The tumor microenvironment

被引：179
作者：
Weber, Cynthia E. [1 ]
Kuo, Paul C. [1 ]
机构：
[1] Loyola Univ, Med Ctr, Dept Surg, Inst Oncol,Stritch Sch Med, Maywood, IL 60153 USA
来源：
SURGICAL ONCOLOGY-OXFORD | 2012年 / 21卷 / 03期
关键词：
Tumor microenvironment; Cancer; Cancer Stroma; Metastasis; Inflammation; Angiogenesis; Tumorogenesis; HUMAN BREAST-CANCER; EPITHELIAL-MESENCHYMAL TRANSITION; MATRIX-METALLOPROTEINASE (MMP)-2; GROWTH-FACTOR; STROMAL FIBROBLASTS; GENETIC INSTABILITY; CELLS; EXPRESSION; HYPOXIA; BETA;
D O I：
10.1016/j.suronc.2011.09.001
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The concept of the tumor microenvironment, developed from Paget's "seed and soil" theory is made up of the cancer cells, the stromal tissue, and the extracellular matrix. In this mini-review, each of the components of this dynamic network will be examined. We will show that there are a multitude of complex interactions and a host of molecules involved in tumorogenesis and metastasis. We will further illustrate this notion with examples from the tumor microenvironment of breast cancer. Lastly, we conclude with thoughts about how this will influence the surgical field with examples of therapeutic agents already in use that target aspects of this microenvironment. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：172 / 177
页数：6
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