MicroRNA function in neuronal development, plasticity and disease

被引：163

作者：

Fiore, Roberto

Siegel, Gabriele

Schratt, Gerhard ^{[1
]}

机构：

[1] Univ Heidelberg, Jr Grp SFB488, Interdisziplinares Zentrum Neurowissensch, D-69120 Heidelberg, Germany

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS | 2008年 / 1779卷 / 08期

关键词：

microRNA; differentiation; synapse; nervous system; neurological disease;

D O I：

10.1016/j.bbagrm.2007.12.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The development and function of the nervous system is orchestrated by a plethora of gene regulatory mechanisms. MicroRNAs (miRNAs), an abundant class of small non-coding RNAs, are emerging as important post-transcriptional regulators of gene expression in the brain. MiRNAs function at all stages of neuronal development, ranging from the initial specification of neuronal cell types to the formation and plasticity of synaptic connections between individual neurons. Moreover, links between miRNA dysfunction and neurological diseases become more and more apparent. The study of this novel layer of gene regulation therefore promises to enrich our knowledge of brain function and pathology. (c) 2007 Elsevier B.V. All rights reserved.

引用

收藏

页码：471 / 478

页数：8

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