Levetiracetam in continuous spike waves during slow-wave sleep syndrome

被引：36

作者：

Wang, Shi-Bing ^{[1
]}

Weng, Wen-Chin ^{[1
]}

Fan, Pi-Chuan ^{[1
]}

Lee, Wang-Tso ^{[1
]}

机构：

[1] Natl Taiwan Univ Hosp, Dept Pediat, Taipei 100, Taiwan

来源：

PEDIATRIC NEUROLOGY | 2008年 / 39卷 / 02期

关键词：

D O I：

10.1016/j.pediatrneurol.2008.04.007

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We investigated the clinical characteristics of children with continuous spike waves during slow-wave sleep syndrome and their treatment response to levetiracetam. Five boys and one girl, diagnosed with epilepsy with continuous spike waves during slow-wave sleep syndrome, were enrolled. Their clinical characteristics, including neuroimaging findings, were reviewed. The signs related to continuous spike waves during slow-wave sleep included increased seizure frequency (6/6), impaired responsiveness (3/6), and psychomotor regression (2/6). Magnetic resonance imaging disclosed lissencephaly in one patient, and porencephaly of the left hemisphere in another. The number of antiepileptic drugs before the use of levetiracetam was 0-4 (mean +/- SD, 2.3 +/- 1.5). Five of 6 children demonstrated a good response to levetiracetam, whereas 2 (40%) underwent a relapse of electrical status epilepticus during sleep pattern on electroencephalograms 4 and 5 months after clinical improvement. Both were 5 years old. The most common presenting sign in children with continuous spike waves during slow-wave sleep syndrome is increasing seizure frequency. Levetiracetam is effective in treating children with continuous spike waves during slow-wave sleep syndrome. However, the relapse rate of continuous spike waves during slow-wave sleep syndrome remains high in young children. (C) 2008 by Elsevier Inc. All rights reserved.

引用

页码：85 / 90

页数：6