Gadolinium-based nanoparticles for theranostic MRI-radiosensitization

被引：88
作者：
Lux, Francois [1 ]
Sancey, Lucie [1 ]
Bianchi, Andrea [2 ]
Cremillieux, Yannick [2 ]
Roux, Stephane [3 ]
Tillement, Olivier [1 ]
机构：
[1] Univ Lyon 1, Inst Lumiere Mat, CNRS, UMR5306, F-69622 Villeurbanne, France
[2] Univ Bordeaux, Ctr Resonance Magnet Syst Biol, CNRS, UMR5536, Bordeaux, France
[3] Univ Franche Comte, Inst UTINAM, CNRS, UMR6213, F-25030 Besancon, France
来源：
NANOMEDICINE | 2015年 / 10卷 / 11期
关键词：
gadolinium; MRI; multimodality; nanoparticles; oncology; radiotherapy; theranostic; NEUTRON-CAPTURE THERAPY; CONTRAST AGENTS; MAGNETIC-RESONANCE; GOLD NANOPARTICLES; MULTIMODAL CONTRAST; RADIATION-THERAPY; QUANTUM DOTS; PARTICLES; OXIDE; BIODISTRIBUTION;
D O I：
10.2217/nnm.15.30
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
A rapid development of gadolinium-based nanoparticles is observed due to their attractive properties as MRI-positive contrast agents. Indeed, they display high relaxivity, adapted biodistribution and passive uptake in the tumor thanks to enhanced permeability and retention effect. In addition to these imaging properties, it has been recently shown that they can act as effective radiosensitizers under different types of irradiation (radiotherapy, neutron therapy or hadron therapy). These new therapeutic modalities pave the way to therapy guided by imaging and to personalized medicine.
引用
收藏
页码：1801 / 1815
页数：15
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