The effect of formononetin on the proliferation and migration of human umbilical vein endothelial cells and its mechanism

被引：12

作者：

Liang, Chunmei ^{[1
]}

Zhou, Anwei ^{[2
]}

Sui, Chengliang ^{[1
]}

Huang, Zhaoquan ^{[3
]}

机构：

[1] Guilin Med Univ, Sch Clin Med Coll, Guilin 541004, Peoples R China

[2] Guilin Med Univ, Key Lab Tumor Immunol & Microenvironm Regulat, Guilin 541004, Peoples R China

[3] Guilin Med Univ, Dept Pathol, Guilin 541004, Peoples R China

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2019年 / 111卷

基金：

中国国家自然科学基金;

关键词：

Formononetin; HUVECs; Proliferation; Migration; HORMONE REPLACEMENT THERAPY; CALYCOSIN INDUCES APOPTOSIS; GROWTH-FACTOR-I; SIGNALING PATHWAY; CANCER CELLS; ESTROGEN; RISK; ANGIOGENESIS; INHIBITION; MENOPAUSE;

D O I：

10.1016/j.biopha.2018.12.049

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Formononetin is one of the main active components of traditional Chinese medicine red clover (Trifolium pratense L). Prior studies have demonstrated that formononetin is a typical phytoestrogen and exhibits an estrogen-like effect that protects the cardiovascular system with minimal side effects. In this study, we further investigated the role of formononetin in human umbilical vein endothelial cells (HUVECs) and its potential molecular mechanisms. We founded that formononetin promotes proliferation and migration of HUVECs as assessed by the MTT and wound healing assays. Meanwhile, insulin-like growth factor 1 (IGF-1) and intercellular adhesion molecule 1 (ICAM-1) protein levels were increased in a dose-dependent manner. Our findings illustrated that formononetin exhibits a protective effect on HUVECs, and the molecular mechanisms may correlate with IGF-1R and ICAM-1, as well as upregulation of vascular endothelial growth factor (VEGF) and activation of extracellular signal-regulated kinase (ERK).

引用

页码：86 / 90

页数：5

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