New methymycin derivatives of Streptomyces venezuelae ATCC 15439 and their inhibitory effects on human T cell proliferation mediated by PMA/ionomycin

被引：7

作者：

Ding, Rong ^{[1
]}

Tang, Jinshan ^{[2
]}

Gao, Hao ^{[2
]}

Li, Ting ^{[3
]}

Zhou, Hua ^{[3
]}

Liu, Liang ^{[3
]}

Yao, Xin-Sheng ^{[1
,2
]}

机构：

[1] Shenyang Pharmaceut Univ, Coll Tradit Chinese Mat Med, Shenyang 110016, Peoples R China

[2] Jinan Univ, Coll Pharm, Inst Tradit Chinese Med & Nat Prod, Guangzhou 510632, Guangdong, Peoples R China

[3] Macau Univ Sci & Technol, State Key Lab Qual Res Chinese Med, Taipa, Macau, Peoples R China

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2012年 / 35卷 / 09期

关键词：

Streptomyces venezuelae ATCC 15439; Methymycin derivatives; Anti-inflammatory activity; 12-and 14-membered macrolides; MACROLIDE BIOSYNTHESIS; STEREOCHEMISTRY; CONSTRUCTION; DESOSAMINE; ACTIVATION; AGLYCONES; PATHWAY;

D O I：

10.1007/s12272-012-0907-z

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two new methymycin derivatives, 3'-demethylmethymycin (1) and 3'-demethyldeoxymethymycin (2), together with seven known ones (3-9), were obtained from the strain Streptomyces venezuelae ATCC 15439. Their structures were determined on the basis of IR, MS, 1D and 2D NMR data. In addition, the inhibitory effects of all the compounds on human T cell proliferation mediated by PMA/ionomycin were evaluated. The data suggested for the first time that methymycin derivatives have potential anti-inflammatory activity.

引用

页码：1567 / 1572

页数：6

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