Rubicordins A-C, new cyclopeptides from Rubia cordifolia with cytotoxicity and inhibiting NF-κB signaling pathway

被引：29

作者：

Chen, Xiao-Qiang ^{[3
,4
]}

Zhao, Si-Meng ^{[3
]}

Wang, Zhe ^{[3
]}

Zeng, Guang-Zhi ^{[3
]}

Huang, Mao-Bo ^{[3
]}

Tan, Ning-Hua ^{[1
,2
,3
]}

机构：

[1] China Pharmaceut Univ, Dept Nat Med Chem, Nanjing 210009, Jiangsu, Peoples R China

[2] China Pharmaceut Univ, State Key Lab Nat Med, Nanjing 210009, Jiangsu, Peoples R China

[3] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China

[4] Northeast Forestry Univ, Key Lab Forest Plant Ecol, Minist Educ, Harbin 150040, Peoples R China

来源：

TETRAHEDRON | 2015年 / 71卷 / 52期

基金：

中国国家自然科学基金;

关键词：

Rubia cordifolia; Rubicordins A-C; Cyclopeptides; Cytotoxicity; NF-kappa B signaling pathway; ANTITUMOR CYCLIC HEXAPEPTIDES; BREAST-CANCER CELLS; RA-V; ABSOLUTE-CONFIGURATION; MARFEYS METHOD; RUBIYUNNANINS; APOPTOSIS;

D O I：

10.1016/j.tet.2015.10.044

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Three new cyclic hexapeptides, named as rubicordins A-C (1-3), together with seven known ones (4-10) were isolated from the roots and rhizomes of Rubia cordifolia. Their structures were elucidated by spectroscopic analysis, and the cytotoxic and NF-kappa B signaling pathway activities were tested. The results indicated that 1-10 showed cytotoxicity against SGC-7901, A549 or Hela cancer cell lines, and 1-3 inhibited NF-kappa B signaling pathway. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：9673 / 9678

页数：6

共 27 条

[1]

[Anonymous], 2011, PHARM PEOPL REP CHIN, P218

[2]

Bik-San C, 2015, SCIENCE, V347, pS45

[3]

Du Liang-Cheng, 2009, Acta Botanica Yunnanica, V31, P374, DOI 10.3724/SP.J.1143.2009.09093

[4] Rubiyunnanins A and B, two novel cyclic hexapeptides from Rubia yunnanensis [J].

Fan, Jun-Ting ;

Chen, Yi-Shan ;

Xu, Wen-Yan ;

Du, Liangcheng ;

Zeng, Guang-Zhi ;

Zhang, Yu-Mei ;

Su, Jia ;

Li, Yan ;

Tan, Ning-Hua .

TETRAHEDRON LETTERS, 2010, 51 (52) :6810-6813

[5] Rubiyunnanins C-H, cytotoxic cyclic hexapeptides from Rubia yunnanensis inhibiting nitric oxide production and NF-κB activation [J].

Fan, Jun-Ting ;

Su, Jia ;

Peng, Yan-Min ;

Li, Yan ;

Li, Jia ;

Zhou, Yu-Bo ;

Zeng, Guang-Zhi ;

Yan, He ;

Tan, Ning-Hua .

BIOORGANIC & MEDICINAL CHEMISTRY, 2010, 18 (23) :8226-8234

[6] Plant cyclopeptide RA-V kills human breast cancer cells by inducing mitochondria-mediated apoptosis through blocking PDK1-AKT interaction [J].

Fang, Xian-Ying ;

Chen, Wei ;

Fan, Jun-Ting ;

Song, Ran ;

Wang, Lu ;

Gu, Yan-Hong ;

Zeng, Guang-Zhi ;

Shen, Yan ;

Wu, Xue-Feng ;

Tan, Ning-Hua ;

Xu, Qiang ;

Sun, Yang .

TOXICOLOGY AND APPLIED PHARMACOLOGY, 2013, 267 (01) :95-103

[7] Further application of advanced Marfey's method for determination of absolute configuration of primary amino compound [J].

Fujii, K ;

Shimoya, T ;

Ikai, Y ;

Oka, H ;

Harada, K .

TETRAHEDRON LETTERS, 1998, 39 (17) :2579-2582

[8] A nonempirical method using LC/MS for determination of the absolute configuration of constituent amino acids in a peptide: Combination of Marfey's method with mass spectrometry and its practical application [J].

Fujii, K ;

Ikai, Y ;

Oka, H ;

Suzuki, M ;

Harada, K .

ANALYTICAL CHEMISTRY, 1997, 69 (24) :5146-5151

[9]

He Min, 1993, Acta Botanica Yunnanica, V15, P408

[10] O-Seco-RA-XXIV, a possible precursor of an antitumor peptide RA-XXIV, from Rubia cordifolia L. [J].

Hitotsuyanagi, Yukio ;

Kusano, Jun-ichi ;

Kim, Ik-Hwi ;

Hasuda, Tomoyo ;

Fukaya, Haruhiko ;

Takeya, Koichi .

PHYTOCHEMISTRY LETTERS, 2012, 5 (02) :335-339

← 1 2 3 →