Recent Advances in BLV Research

被引：69

作者：

Barez, Pierre-Yves ^{[1
,2
]}

de Brogniez, Alix ^{[1
,2
]}

Carpentier, Alexandre ^{[1
,2
]}

Gazon, Helene ^{[1
,2
]}

Gillet, Nicolas ^{[1
,2
]}

Gutierrez, Geronimo ^{[3
]}

Hamaidia, Malik ^{[1
,2
]}

Jacques, Jean-Rock ^{[1
,2
]}

Perike, Srikanth ^{[1
,2
]}

Sriramareddy, Sathya Neelature ^{[1
,2
]}

Renotte, Nathalie ^{[1
,2
]}

Staumont, Bernard ^{[1
,2
]}

Reichert, Michal ^{[4
]}

Trono, Karina ^{[3
]}

Willems, Luc ^{[1
,2
]}

机构：

[1] Univ Liege ULg, Mol & Cellular Epigenet GIGA, B-4000 Liege, Belgium

[2] Univ Liege ULg, Mol Biol Gembloux Agrobio Tech, B-4000 Liege, Belgium

[3] INTA, Ctr Invest Ciencias Vet & Agron, Inst Virol, RA-1712 Castelar, Argentina

[4] Natl Inst Vet Res, Dept Pathol, PL-24110 Pulawy, Poland

来源：

VIRUSES-BASEL | 2015年 / 7卷 / 11期

关键词：

BLV; HTLV-1; Tax; microRNA; vaccine; HDAC; BOVINE LEUKEMIA-VIRUS; CHRONIC LYMPHOCYTIC-LEUKEMIA; LONG TERMINAL REPEAT; IN-VIVO; TRANSMEMBRANE PROTEIN; VIRAL EXPRESSION; INFECTED SHEEP; CELL TURNOVER; VALPROIC ACID; APOPTOSIS;

D O I：

10.3390/v7112929

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Different animal models have been proposed to investigate the mechanisms of Human T-lymphotropic Virus (HTLV)-induced pathogenesis: rats, transgenic and NOD-SCID/cnull (NOG) mice, rabbits, squirrel monkeys, baboons and macaques. These systems indeed provide useful information but have intrinsic limitations such as lack of disease relevance, species specificity or inadequate immune response. Another strategy based on a comparative virology approach is to characterize a related pathogen and to speculate on possible shared mechanisms. In this perspective, bovine leukemia virus (BLV), another member of the deltaretrovirus genus, is evolutionary related to HTLV-1. BLV induces lymphoproliferative disorders in ruminants providing useful information on the mechanisms of viral persistence, genetic determinants of pathogenesis and potential novel therapies.

引用

页码：6080 / 6088

页数：9

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