Zinc(II) mediated asymmetric aldol condensation catalyzed by chiral aziridine ligands

被引：9

作者：

Pieczonka, Adam M. ^{[1
]}

Jarzynski, Szymon ^{[1
]}

Wujkowska, Zuzanna ^{[1
]}

Lesniak, Stanislaw ^{[1
]}

Rachwalski, Michal ^{[1
]}

机构：

[1] Univ Lodz, Fac Chem, Dept Organ & Appl Chem, PL-91403 Lodz, Poland

来源：

TETRAHEDRON LETTERS | 2015年 / 56卷 / 46期

关键词：

Aldol condensation; Asymmetric synthesis; Aziridines; Chiral ligands; Aziridine alcohols and ethers; HIGHLY EFFICIENT CATALYSTS; ADDITIONS; ALCOHOLS; ACID; ORGANOCATALYSTS; DIETHYLZINC;

D O I：

10.1016/j.tetlet.2015.10.027

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Exploration of chiral aziridine ethers and aziridine alcohols as ligands for the Zn(II) catalyzed enantio-selective direct aldol condensations reaction is described. The reaction of acetone with NO2-substituted aromatic aldehydes in the presence of water gave the desired adducts in moderate chemical yields (40-70%) and good to excellent enantiomeric excesses (80-98% ee). (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：6506 / 6507

页数：2

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