Evaluation of mortality, disease activity, treatment, clinical and immunological features of adult and late onset systemic Lupus erythematosus

被引:30
作者
Cartella, Stefania [1 ]
Cavazzana, Ilaria [1 ]
Ceribelli, Angela [2 ]
Inverardi, Flora [3 ]
Tincani, Angela [1 ]
Franceschini, Franco [1 ]
机构
[1] Spedali Civil Brescia, I-25123 Brescia, Italy
[2] Univ Florida, Coll Dent, Gainesville, FL USA
[3] IRCCS Policlin S Matteo, Pavia, Italy
关键词
Age; autoimmunity; ECLAM; sicca; treatment condition; MULTIETHNIC US COHORT; 3; ETHNIC-GROUPS; DAMAGE; ANTIBODIES; ATHEROSCLEROSIS; MANIFESTATIONS; IDENTIFICATION; PROGNOSIS; WORKSHOP; SURVIVAL;
D O I
10.3109/08916934.2013.794793
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Objectives: We retrospectively compared disease activity, treatment, clinical and laboratory features, and rate of mortality of 535 SLE patients with adult and late disease onset. Methods: patients were divided into two groups based on the onset of the disease before or after 50 years of age. Clinical data were collected from medical reports. Disease activity was measured by ECLAM score. Parameters were compared by chi(2)-test, Fisher's test, Student's t or the Mann Whitney test. Results: Forty patients (7.5%) were included in the late SLE onset group (group A), while 495 (92.5%) in the adult SLE onset group (group B). Sicca symptoms were more frequent in group A (p<0.0008), while glomerulonephritis (p<0.0069), reduced C3 (p<0.0006) and low C3 (p<0.00002) and C4 levels (p<0.0006) were more prevalent in group B. Twenty-two deaths (4.3%) were recorded: 14 (2.8%) in group B and 8 (20%) in group A. Deaths were mainly due to infections in group B (28.5%) and cardiovascular events in group A (50%). A lower use of HCQ and LDA were recorded in deceased versus living patients (p<0.0001 and 0.0166, respectively), while a higher ECLAM score was measured at onset in dead versus living patients (p<0.048). Conclusions: Late onset SLE occurred in 7.5% of patients and it was associated with sicca symptoms. The use of HCQ and LDA is positively correlated with survival. Death in late onset SLE occurred more frequently for cardiovascular involvement. Higher disease activity at onset of the disease might represent a poor prognostic factor for death in adult onset.
引用
收藏
页码:363 / 368
页数:6
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