Molecular nature of methicillin-resistant Staphylococcus aureus derived from explosive nosocomial outbreaks of the 1980s in Japan

被引：38

作者：

Taneike, I ^{[1
]}

Otsuka, T ^{[1
]}

Dohmae, S ^{[1
]}

Saito, K ^{[1
]}

Ozaki, K ^{[1
]}

Takano, M ^{[1
]}

Higuchi, W ^{[1
]}

Takano, T ^{[1
]}

Yamamoto, T ^{[1
]}

机构：

[1] Niigata Univ, Grad Sch Med & Dent Sci, Dept Infect Dis Control & Int Med, Div Bacteriol, Niigata, Japan

来源：

FEBS LETTERS | 2006年 / 580卷 / 09期

关键词：

community-acquired MRSA; hospital-acquired MRSA; nosocomial outbreak; Panton-Valentine leukocidin; adhesin; resistance;

D O I：

10.1016/j.febslet.2006.03.049

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) with Panton-Valentine leukocidin (PVL) genes is increasing worldwide. Nosocomial outbreak-derived (hospital-acquired) MRSA (HA-MRSA) in Japan in the 1980s was also largely PVL+. PVL+ HA-MRSA and CA-MRSA shared the same multi-locus sequence type (ST30) and methicillin resistance cassette (SCCmecIV), but were divergent in oxacillin resistance, spa typing, PFGE analysis or clfA gene analysis. PVL+ HA-MRSA, which probably originated in PVL+ S. aureus ST30, was highly adhesive (carrying cna and bbp genes), highly-toxic (carrying luk(PV), and sea genes) and highly drug-resistant. PVL+ HA-MRSA was once replaced by other PVL- HA-MRSA (e.g., ST5), and is re-emerging as CA-MRSA. (c) 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：2323 / 2334

页数：12

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