Fabrication of a Modified Electrode Based on Fe3O4-Graphene Oxide Hybrid Composite: Applying to Simultaneous Determination of Adenine and Guanine in DNA

被引：10

作者：

Xie, Qianjie ^{[2
]}

Chen, Xiang-yu ^{[2
]}

Zhang, Hanzhi ^{[2
]}

Liu, Mengdi ^{[2
]}

Wang, Qian ^{[3
]}

Zhang, Xin ^{[1
]}

Shen, Yehua ^{[2
]}

Yang, Fengchun ^{[2
]}

机构：

[1] NW Univ Xian, Inst Analyt Sci, Shaanxi Prov Key Lab Electroanalyt Chem, Xian 710069, Shaanxi, Peoples R China

[2] NW Univ Xian, Coll Chem & Mat Sci, Key Lab Synthet & Nat Funct Mol Chem, Minist Educ, Xian 710069, Shaanxi, Peoples R China

[3] Xian Univ Posts & Telecommun, Sch Telecommun & Informat Engn, Xian 710121, Shaanxi, Peoples R China

来源：

ELECTROANALYSIS | 2015年 / 27卷 / 09期

关键词：

Fe3O4; nanoparticles; Graphene oxide; Adenine; Guanine; Simultaneous determination; DNA; GLASSY-CARBON ELECTRODE; ELECTROCHEMICAL SENSOR; MASS-SPECTROMETRY; ASCORBIC-ACID; URIC-ACID; GRAPHENE; NANOCOMPOSITE; NANOPARTICLES; FILM; OXIDATION;

D O I：

10.1002/elan.201500186

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A Fe3O4-graphene oxide hybrid composite (Fe3O4- GO) was synthesized and used to construct a novel electrochemical sensor for the simultaneous detection of adenine and guanine. The Fe3O4-GO based electrochemical sensor exhibits linear ranges of 0.05-25 mu M and 0.05-25 mu M with detection limits of 4 nM and 3 nM for adenine and guanine, respectively. This method was applied in the determination of guanine and adenine in many samples with satisfying results. The value of (G+C)/(A+T) in DNA was calculated to be 0.7536. The sensor exhibits some advantages, such as rapidity, good reproducibility and long-term stability.

引用

页码：2201 / 2208

页数：8

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