Kidney Transplantation in Systemic Amyloidosis

被引：8

作者：

Angel-Korman, Avital ^{[1
,2
]}

Havasi, Andrea ^{[1
,2
]}

机构：

[1] Boston Univ, Sch Med, Dept Med, Renal Sect, Boston, MA 02118 USA

[2] Boston Univ, Sch Med, Amyloidosis Ctr, Boston, MA 02118 USA

来源：

TRANSPLANTATION | 2020年 / 104卷 / 10期

关键词：

STEM-CELL TRANSPLANTATION; LIGHT-CHAIN AMYLOIDOSIS; HIGH-DOSE MELPHALAN; MINIMAL RESIDUAL DISEASE; SOLID-ORGAN TRANSPLANTATION; STAGE RENAL-DISEASE; A-I AMYLOIDOSIS; LIVER-TRANSPLANTATION; TRANSTHYRETIN AMYLOIDOSIS; HEREDITARY FIBRINOGEN;

D O I：

10.1097/TP.0000000000003170

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The present review discusses current developments and outcomes of renal transplantation in systemic amyloidosis. Amyloidosis can wreak havoc on the architecture and functioning of the kidneys, leading to end-stage renal disease. In recent years, the available treatments, especially for light-chain amyloidosis but also for several of the underlying inflammatory diseases that cause amyloid A amyloidosis have expanded leading to prolonged survival albeit frequently with renal failure. At the same time, there are also increasing numbers of patients diagnosed with one of the inherited forms of amyloidosis for which currently there is no targeted treatment available and, in some cases, renal failure is unavoidable. Due to the complex nature of the pathophysiology and treatment of these diseases, it can be very challenging for the clinician to determine whether or not it is appropriate to refer an affected individual for kidney transplantation. Determining eligibility criteria, as well as peritransplant and posttransplant management, requires a multidisciplinary approach with close monitoring and follow-up.

引用

页码：2035 / 2047

页数：13

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