Facile synthesis of 3-aryl-5-(2-oxopyrrolidin-1-yl)- and 5-(pyridin-4-yl)-4,5-dihydroisoxazoles via 1,3-dipolar cycloaddition under mild conditions

被引：15

作者：

Gong, Yan ^{[1
]}

Wang, Yong ^{[1
]}

Zhao, Wen-Tao ^{[1
]}

Tang, Xiang-Yang ^{[1
]}

机构：

[1] Tianjin Univ, Dept Chem, Tianjin 300072, Peoples R China

来源：

JOURNAL OF CHEMICAL RESEARCH | 2013年 / 08期

基金：

中国国家自然科学基金;

关键词：

1,3-dipolarcycloaddition; 3-aryl-5-(2-oxopyrrolidin-1-yl)-4,5-dihydroisoxazoles; 3-aryl-5-(pyridin-4-yl)-4,5-dihydroisoxazoles; nitrile oxides; POTENT; DISCOVERY;

D O I：

10.3184/174751913X13735527483211

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A convenient and efficient synthetic approach for the synthesis of 5-substituted 3-aryl-4,5-dihydroisoxazoles is reported. In the presence of triethylamine, a series of hydroximoyl chlorides were transformed into nitrile oxides, followed by reaction with N-vinyl-2-pyrrolidinone (or 4-vinylpyridine) by a 1,3-dipolar cycloaddition to give novel 4,5-dihydroisoxazole derivatives.

引用

页码：499 / 502

页数：4

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